Abolfazli Nader, Jabali Sahar, Saleh Saber Fariba, Babaloo Zohreh, Shirmohammadi Adileh
Associate Professor, Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Assistant Professor, Department of Periodontics, Faculty of Dentistry, Urmia University of Medical Sciences, Urmia, Iran.
J Dent Res Dent Clin Dent Prospects. 2015 Winter;9(1):11-7. doi: 10.15171/joddd.2015.003. Epub 2015 Mar 4.
Background and aims. Visfatin, mainly secreted by visceral adipose tissue, especially by macrophages, plays an important role in regulating the defense and immune functions, and functions as a growth factor, a cytokine, an enzyme and more importantly as a proinflammatory mediator. The aim of the present study was to evaluate the effect of non-surgical periodontal treatment on serum and salivary levels of visfatin in patients with generalized moderate-to-severe chronic periodontitis. Materials and methods. Eighteen patients with generalized moderate-to-severe chronic periodontitis were selected based on periodontal parameters of gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL) and radiographic parameters. Serum and salivary samples were collected at baseline and one month following non-surgical periodontal therapy (scaling and root planing ([SRP]). Visfatin levels were measured using an ELISA kit. Data were analyzed by SPSS 15, using paired t-test and Pearson's correlation coefficient. Results. Mean salivary and serum levels of visfatin significantly decreased after non-surgical periodontal treatment (P<0.05). Changes in salivary visfatin levels were more prominent. Conclusion. According to the findings of this study it seems that there is a direct relationship between periodontal tissue inflammation and disease activity with salivary and serum visfatin levels.
背景与目的。内脂素主要由内脏脂肪组织分泌，尤其是巨噬细胞，在调节防御和免疫功能中起重要作用，并且作为一种生长因子、细胞因子、酶，更重要的是作为促炎介质发挥作用。本研究的目的是评估非手术牙周治疗对重度慢性牙周炎患者血清和唾液内脂素水平的影响。材料与方法。根据牙龈指数（GI）、探诊深度（PPD）、临床附着丧失（CAL）的牙周参数和影像学参数，选取18例重度慢性牙周炎患者。在基线和非手术牙周治疗（龈上洁治和根面平整[SRP]）后1个月采集血清和唾液样本。使用酶联免疫吸附测定（ELISA）试剂盒测量内脂素水平。数据采用SPSS 15软件进行分析，使用配对t检验和Pearson相关系数。结果。非手术牙周治疗后，唾液和血清内脂素的平均水平显著降低（P<0.05）。唾液内脂素水平的变化更显著。结论。根据本研究的结果，牙周组织炎症和疾病活动与唾液和血清内脂素水平之间似乎存在直接关系。
