Liu Ye, Zhu Xiao-Ying, Zhang Xiao-Jin, Kuo Sheng-Han, Ondo William G, Wu Yun-Cheng
Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100, Haining Road, Shanghai, 200080 People's Republic of China.
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, USA.
Transl Neurodegener. 2017 Dec 21;6:35. doi: 10.1186/s40035-017-0105-5. eCollection 2017.
Rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease (PD) are two distinct clinical diseases but they share some common pathological and anatomical characteristics. This study aims to confirm the clinical features of RBD in Chinese PD patients.
One hundred fifty PD patients were enrolled from the Parkinson`s disease and Movement Disorders Center in Department of Neurology, Shanghai General Hospital from January 2013 to August 2014. This study examined PD patients with or without RBD as determined by the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ), assessed motor subtype by Unified PD Rating Scale (UPDRS) III at "on" state, and compared the sub-scale scores representing tremor, rigidity, appendicular and axial. Investigators also assessed the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), and Parkinson's disease Sleep Scale (PDSS).
One hundred fourty one PD patients entered the final study. 30 (21.28%) PD patients had probable RBD (pRBD) diagnosed with a RBDSQ score of 6 or above. There were no significant differences for age, including age of PD onset and PD duration, gender, smoking status, alcohol or coffee use, presence of anosmia or freezing, UPDRS III, and H-Y stages between the pRBD and pRBD groups. pRBD group had lower MMSE scores, higher PDSS scores, and pRBD PD patients had more prominent proportion in anxiety, depression, constipation, hallucination and a greater prevalence of orthostatic hypotension.
pRBD PD patients exhibited greater changes in non-motor symptoms. However, there was no increase in motor deficits.
快速眼动睡眠行为障碍（RBD）和帕金森病（PD）是两种不同的临床疾病，但它们具有一些共同的病理和解剖学特征。本研究旨在确认中国帕金森病患者中RBD的临床特征。
2013年1月至2014年8月，从上海交通大学医学院附属瑞金医院神经内科帕金森病及运动障碍中心招募了150例帕金森病患者。本研究通过快速眼动睡眠行为障碍筛查问卷（RBDSQ）确定有无RBD的帕金森病患者，在“开”状态下用统一帕金森病评定量表（UPDRS）III评估运动亚型，并比较代表震颤、强直、肢体和轴性的分量表得分。研究者还评估了汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）、简易精神状态检查表（MMSE）、临床痴呆评定量表（CDR）和帕金森病睡眠量表（PDSS）。
141例帕金森病患者进入最终研究。30例（21.28%）帕金森病患者被诊断为可能的RBD（pRBD），RBDSQ评分≥6分。pRBD组和非pRBD组在年龄（包括帕金森病发病年龄和病程）、性别、吸烟状况、饮酒或咖啡饮用情况、嗅觉减退或冻结现象、UPDRS III以及H-Y分期方面无显著差异。pRBD组MMSE评分较低，PDSS评分较高，且pRBD帕金森病患者在焦虑、抑郁、便秘、幻觉方面的比例更高，体位性低血压的患病率也更高。
pRBD帕金森病患者在非运动症状方面有更大变化。然而，运动功能障碍并未增加。
