Frangos J A, Eskin S G, McIntire L V, Ives C L
Science. 1985 Mar 22;227(4693):1477-9. doi: 10.1126/science.3883488.
Endothelial cell functions, such as arachidonic acid metabolism, may be modulated by membrane stresses induced by blood flow. The production of prostacyclin by primary human endothelial cell cultures subjected to pulsatile and steady flow shear stress was measured. The onset of flow led to a sudden increase in prostacyclin production, which decreased to a steady rate within several minutes. The steady-state production rate of cells subjected to pulsatile shear stress was more than twice that of cells exposed to steady shear stress and 16 times greater than that of cells in stationary culture.
内皮细胞功能，如花生四烯酸代谢，可能会受到血流诱导的膜应力调节。对经受脉动和稳定流剪切应力的原代人内皮细胞培养物中前列环素的产生进行了测量。血流开始导致前列环素产生突然增加，在几分钟内降至稳定速率。经受脉动剪切应力的细胞的稳态产生速率是暴露于稳定剪切应力的细胞的两倍多，是静态培养细胞的16倍。
