Liu Sifan, Wang Shidong, Zhang Nan, Li Peng
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University; State Key Laboratory for Digestive Health; National Clinical Research Center for Digestive Diseases, Beijing, China.
Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China.
J Oral Microbiol. 2024 Jun 3;16(1):2355823. doi: 10.1080/20002297.2024.2355823. eCollection 2024.
Microbiomes are essential components of the human body, and their populations are substantial. Under normal circumstances, microbiomes coexist harmoniously with the human body, but disturbances in this equilibrium can lead to various diseases. The oral microbiome is involved in the occurrence and development of many oral and gastrointestinal diseases. This review focuses on the relationship between oral microbiomes and oral and upper gastrointestinal diseases, and therapeutic strategies aiming to provide valuable insights for clinical prevention and treatment.
To identify relevant studies, we conducted searches in PubMed, Google Scholar, and Web of Science using keywords such as "oral microbiome," "oral flora, " "gastrointestinal disease, " without any date restrictions. Subsequently, the retrieved publications were subject to a narrative review.
In this review, we found that oral microbiomes are closely related to oral and gastrointestinal diseases such as periodontitis, dental caries, reflux esophagitis, gastritis, and upper gastrointestinal tumors (mainly the malignant ones). Oral samples like saliva and buccal mucosa are not only easy to collect, but also display superior sample stability compared to gastrointestinal tissues. Consequently, analysis of the oral microbiome could potentially serve as an efficient preliminary screening method for high-risk groups before undergoing endoscopic examination. Besides, treatments based on the oral microbiomes could aid early diagnosis and treatment of these diseases.
Oral microbiomes are essential to oral and gastrointestinal diseases. Therapies centered on the oral microbiomes could facilitate the early detection and management of these conditions.
微生物群是人体的重要组成部分，其数量众多。在正常情况下，微生物群与人体和谐共存，但这种平衡的紊乱会导致各种疾病。口腔微生物群参与许多口腔和胃肠道疾病的发生和发展。本综述聚焦于口腔微生物群与口腔及上胃肠道疾病之间的关系以及治疗策略，旨在为临床预防和治疗提供有价值的见解。
为了识别相关研究，我们在PubMed、谷歌学术和科学网中使用“口腔微生物群”“口腔菌群”“胃肠道疾病”等关键词进行检索，无任何日期限制。随后，对检索到的出版物进行叙述性综述。
在本综述中，我们发现口腔微生物群与牙周炎、龋齿、反流性食管炎、胃炎和上胃肠道肿瘤（主要是恶性肿瘤）等口腔和胃肠道疾病密切相关。唾液和颊黏膜等口腔样本不仅易于采集，而且与胃肠道组织相比具有更好的样本稳定性。因此，口腔微生物群分析有可能作为高危人群内镜检查前的一种高效初步筛查方法。此外，基于口腔微生物群的治疗有助于这些疾病的早期诊断和治疗。
口腔微生物群对口腔和胃肠道疾病至关重要。以口腔微生物群为中心的治疗方法有助于这些疾病的早期检测和管理。
