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孕早期的积极应对与不良妊娠结局

Proactive Coping in Early Pregnancy and Adverse Pregnancy Outcomes.

作者信息

Cersonsky Tess E K, Fain Audra C, Lewkowitz Adam K, Werner Erika F, Miller Emily S, Clark Melissa A, Ayala Nina K

机构信息

Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Department of Obstetrics & Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

出版信息

Int J Womens Health. 2024 May 30;16:979-985. doi: 10.2147/IJWH.S442977. eCollection 2024.

Abstract

OBJECTIVE

Outside of pregnancy, proactive coping has been associated with both mental and physical well-being and with improved quality of life in chronic disease, but its effects in pregnancy are understudied. Our objective was to evaluate whether early pregnancy proactive coping was associated with adverse perinatal outcomes.

STUDY DESIGN

This was a planned secondary analysis of nulliparous pregnant people recruited from a tertiary care center. Participants completed a validated assessment of proactive coping () at 8-20 weeks and were followed longitudinally through delivery. Detailed pregnancy and delivery data were collected by trained research personnel. The primary outcome was a composite of adverse perinatal outcomes including unplanned cesarean delivery, gestational diabetes, and hypertensive disorders of pregnancy. Secondary analyses included individual perinatal composite components and a neonatal morbidity composite measure. Multivariate regression compared adverse perinatal outcomes by Proactive Coping Scale quartile, controlling for a priori confounders.

RESULTS

Of the 281 parturients, the median Proactive Coping Scale score was 45.0 (range 25-55), and 47% experienced an adverse perinatal outcome. After adjusting for confounders, those in the lowest Proactive Coping Scale quartile had 2.2 times higher odds of experiencing an adverse perinatal outcome compared to those in the highest Proactive Coping Scale quartile. There were no differences in odds of the individual composite components or the adverse neonatal outcome.

CONCLUSION

Lower early pregnancy proactive coping scores are associated with significant increase in adverse perinatal outcomes. Interventions that target improving proactive coping may be a novel mechanism for reducing perinatal morbidity.

摘要

目的

在非孕期,积极应对与身心健康以及慢性病患者生活质量的改善相关,但在孕期其影响尚未得到充分研究。我们的目的是评估孕早期积极应对是否与不良围产期结局相关。

研究设计

这是一项对从三级医疗中心招募的初产妇进行的计划二次分析。参与者在孕8 - 20周完成了一项经过验证的积极应对评估(),并纵向随访至分娩。由经过培训的研究人员收集详细的妊娠和分娩数据。主要结局是包括计划外剖宫产、妊娠期糖尿病和妊娠高血压疾病在内的不良围产期结局的综合指标。二次分析包括个体围产期综合指标的组成部分以及新生儿发病率综合指标。多变量回归通过积极应对量表四分位数比较不良围产期结局,并对先验混杂因素进行控制。

结果

在281名产妇中,积极应对量表的中位数得分为45.0(范围25 - 55),47%的产妇经历了不良围产期结局。在对混杂因素进行调整后,积极应对量表得分处于最低四分位数的产妇发生不良围产期结局的几率是得分处于最高四分位数产妇的2.2倍。个体综合指标组成部分或不良新生儿结局的几率没有差异。

结论

孕早期较低的积极应对得分与不良围产期结局的显著增加相关。针对改善积极应对的干预措施可能是降低围产期发病率的一种新机制。

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本文引用的文献

1
Early pregnancy dispositional optimism and pregnancy outcomes among nulliparous people.初产妇的孕期倾向性乐观与妊娠结局。
Am J Obstet Gynecol MFM. 2023 Nov;5(11):101155. doi: 10.1016/j.ajogmf.2023.101155. Epub 2023 Sep 19.

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