López Cristina, Fischer Anja, Rosenwald Andreas, Siebert Reiner, Ott German, Kurz Katrin S
Universität Würzburg Institut für Pathologie Würzburg Germany.
Universität Ulm und Universitätsklinikum Ulm Institut für Humangenetik Ulm Germany.
Med Genet. 2024 Mar 6;36(1):59-73. doi: 10.1515/medgen-2024-2005. eCollection 2024 Apr.
The identification of recurrent genomic alterations in tumour cells has a significant role in the classification of mature B- and T-cell lymphomas. Following the development of new technologies, such as next generation sequencing and the improvement of classical technologies such as conventional and molecular cytogenetics, a huge catalogue of genomic alterations in lymphoid neoplasms has been established. These alterations are relevant to refine the taxonomy of the classification of lymphomas, to scrutinize the differential diagnosis within different lymphoma entities and to help assessing the prognosis and clinical management of the patients. Consequently, here we describe the key genetic alterations relevant in mature B- and T-cell lymphomas.
肿瘤细胞中复发性基因组改变的鉴定在成熟B细胞和T细胞淋巴瘤的分类中具有重要作用。随着新技术的发展，如下一代测序，以及传统和分子细胞遗传学等经典技术的改进，已经建立了淋巴肿瘤基因组改变的庞大目录。这些改变对于完善淋巴瘤分类的分类学、仔细检查不同淋巴瘤实体之间的鉴别诊断以及帮助评估患者的预后和临床管理具有重要意义。因此，在此我们描述成熟B细胞和T细胞淋巴瘤中相关的关键基因改变。
