Haines D M, Penhale W J
Vet Immunol Immunopathol. 1985 Jan;8(1-2):149-56. doi: 10.1016/0165-2427(85)90118-7.
Indirect immunofluorescence on normal canine pancreatic tissue fixed in Bouin's solution was used to detect islet cell antibodies in dogs with diabetes mellitus, other endocrine diseases, and pancreatitis. 18 of 25 dogs with diabetes mellitus alone, 2 of 8 dogs with diabetes mellitus and concurrent pancreatitis, and 2 of 2 dogs with diabetes mellitus and concurrent pancreatic exocrine insufficiency were positive for autoantibody. 2 of 12 dogs with hypoadrenocorticism, 3 of 6 dogs with hyperadrenocorticism, 6 of 28 dogs with hypothyroidism and one of 19 dogs with pancreatitis alone were also antibody positive. None of 20 healthy dogs or 20 dogs with disorders other than those of the pancreas or endocrine organs were antibody positive. Islet cell antibodies were demonstrated in dogs with diabetes mellitus and other endocrine disorders. The possibility of autoimmune involvement in the development of diabetes mellitus in the dog should be considered.
采用间接免疫荧光法检测固定于波因氏液中的正常犬胰腺组织，以检测患有糖尿病、其他内分泌疾病和胰腺炎的犬的胰岛细胞抗体。仅患有糖尿病的25只犬中有18只、患有糖尿病并发胰腺炎的8只犬中有2只、患有糖尿病并发胰腺外分泌功能不全的2只犬中有2只自身抗体呈阳性。患有肾上腺皮质功能减退的12只犬中有2只、患有肾上腺皮质功能亢进的6只犬中有3只、患有甲状腺功能减退的28只犬中有6只以及仅患有胰腺炎的19只犬中有1只抗体也呈阳性。20只健康犬或20只患有除胰腺或内分泌器官疾病以外其他疾病的犬均无抗体阳性。在患有糖尿病和其他内分泌疾病的犬中发现了胰岛细胞抗体。应考虑自身免疫参与犬糖尿病发生发展的可能性。
