Universidade Federal do Acre - UFAC, Rio Branco, AC, Brasil.
Departamento de Medicina Veterinária, Universidade Federal de Juiz de Fora - UFJF, Juiz de Fora, MG, Brasil.
Rev Bras Parasitol Vet. 2024 May 31;33(2):e018223. doi: 10.1590/S1984-29612024023. eCollection 2024.
In endemic areas for canine visceral leishmaniasis (CVL), the occurrence of coinfection with other pathogens, such as Ehrlichia spp., has been associated with worsening of the clinical condition. The study aimed to evaluate the occurrence of histological changes in the myocardia of dogs naturally infected with Leishmania chagasi with or without coinfection with Ehrlichia spp.. We evaluated paraffin-embedded myocardial sections from 31 dogs, affected by either L. chagasi alone or coinfected with L. chagasi and Ehrlichia spp., to compare the extent and degree of cardiac damage. The blocks were divided into two groups. G1 (dogs infected only by L. chagasi) and G2 (dogs coinfected with L. chagasi and Ehrlichia spp.). The right atrium free wall, right ventricle free wall, left ventricle, and interventricular septum of all groups were evaluated. Cardiac alterations were observed in 41.93% (52/124) of the fragments evaluated and inflammatory infiltrate was the most common pattern found. The G2 group showed a higher incidence of myocarditis, with 61.53% (32/52), compared to the G1 group, in which 20 out of 72 cases (27.7%) exhibited histopathological changes (p <0.05). These findings confirmed that coinfection can potentiate cardiac damage in dogs.
在犬内脏利什曼病（CVL）的流行地区，与其他病原体（如埃立克体属）的合并感染与临床病情恶化有关。本研究旨在评估自然感染利什曼原虫的犬心肌组织中是否存在组织学变化，以及是否存在埃立克体属的合并感染。我们评估了 31 只犬的石蜡包埋心肌切片，这些犬要么单独感染了利什曼原虫，要么同时感染了利什曼原虫和埃立克体属，以比较心脏损伤的程度和程度。这些块被分为两组。G1 组（仅感染利什曼原虫的犬）和 G2 组（同时感染利什曼原虫和埃立克体属的犬）。评估了各组的右心房游离壁、右心室游离壁、左心室和室间隔。在评估的 124 个片段中，有 41.93%（52/124）观察到心脏改变，最常见的是炎症浸润模式。与 G1 组相比，G2 组心肌炎的发生率更高，61.53%（32/52），而 G1 组中 72 个病例中有 20 个（27.7%）出现组织病理学变化（p<0.05）。这些发现证实，合并感染会加剧犬的心脏损伤。
