Guo Baoqiang, Xu Xiuli, Chi Xuexiu, Wang Min
Department of Endocrinology and Metabolism, The Second People's Hospital of Liaocheng, Liaocheng, 252600, China.
Department of Function (Electroencephalogram Room), The Second People's Hospital of Liaocheng, Liaocheng, 252600, China.
Ir J Med Sci. 2024 Oct;193(5):2293-2299. doi: 10.1007/s11845-024-03720-7. Epub 2024 Jun 5.
Diabetic peripheral neuropathy (DPN) frequently occurs as a secondary condition in individuals with type 2 diabetes mellitus (T2DM).
To explore the relationship of lncRNA FTX and miR-186-5p levels with DPN in T2DM.
The study enrolled 50 patients with T2DM and 45 patients with DPN. Expression levels of FTX and miR-186-5p were measured by RT-qPCR. The levels of MDA, GSH, and SOD in the serum were measured to assess the patients' oxidative stress levels. In addition, the target genes of miR-186-5p were analyzed by bioinformatics.
Serum FTX levels were increased and miR-186-5p levels were decreased in patients with T2DM and DPN. Both of them had high diagnostic value for T2DM and DPN. In addition, FTX and miR-186-5p were risk factors for the onset of DPN in people with T2DM and were significantly correlated with oxidative stress indicators in patients.
FTX and miR-186-5p are closely related to the disease progression of DPN in people with T2DM and may become therapeutic targets for DPN in people with T2DM.
糖尿病周围神经病变（DPN）常作为2型糖尿病（T2DM）患者的继发病症出现。
探讨lncRNA FTX和miR-186-5p水平与T2DM患者DPN的关系。
该研究纳入了50例T2DM患者和45例DPN患者。通过RT-qPCR检测FTX和miR-186-5p的表达水平。检测血清中丙二醛（MDA）、谷胱甘肽（GSH）和超氧化物歧化酶（SOD）的水平，以评估患者的氧化应激水平。此外，通过生物信息学分析miR-186-5p的靶基因。
T2DM和DPN患者血清FTX水平升高，miR-186-5p水平降低。二者对T2DM和DPN均具有较高的诊断价值。此外，FTX和miR-186-5p是T2DM患者发生DPN的危险因素，且与患者的氧化应激指标显著相关。
FTX和miR-186-5p与T2DM患者DPN的疾病进展密切相关，可能成为T2DM患者DPN的治疗靶点。
