Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Science and Technology, Sana'a, Yemen.
PLoS One. 2024 Jun 5;19(6):e0304209. doi: 10.1371/journal.pone.0304209. eCollection 2024.
Non-Hodgkin lymphoma (NHL) is a hematological malignancy that requires effective pharmacotherapy for optimal management. There is limited information regarding Yemeni clinicians' knowledge and practice of NHL pharmacotherapy. This study aims to assess the knowledge and practice of physicians and nurses in Yemen regarding pharmacotherapy of NHL. A cross-sectional study was conducted in Sana'a, Yemen, from January 1, 2022, to January 31, 2023. Two self-administrated and validated questionnaires were distributed to 99 physicians and 164 nurses involved in pharmacotherapy for NHL in different oncology centers and units across Yemen. Convenience samples were used to recruit participants. A binary logistic regression analysis was performed to identify factors associated with nurses' and physicians' knowledge and practice. The correlation coefficient was used to examine the relationship between knowledge and practice. A total of 77 physicians and 105 nurses completed the questionnaires. The results showed that 54.3% of nurses and 66.2% of physicians had poor knowledge of NHL pharmacotherapy. In terms of practice, 83.8% of nurses and 75.3% of physicians exhibited poor practice regarding NHL pharmacotherapy. Multivariable logistic regression analysis identified that nurses who received sufficient information about chemotherapy displayed a significant association with good knowledge, while nurses working in the chemotherapy administration department were significant predictors of good practice. Among physicians, those working in the National Oncology Center (NOC) in Sana'a demonstrated good practice. Correlation analysis revealed a positive relationship between nurses' knowledge and their practice. The study's results confirm deficiencies in knowledge and practice of pharmacotherapy for NHL among physicians and nurses in Yemen. Efforts should be made to enhance their understanding of treatment guidelines and to improve patient care. Improvement in educational programs and training opportunities may contribute to improving patient outcomes in the management of NHL.
非霍奇金淋巴瘤（NHL）是一种血液系统恶性肿瘤，需要有效的药物治疗来实现最佳管理。关于也门临床医生对 NHL 药物治疗的了解和实践，信息有限。本研究旨在评估也门医生和护士在 NHL 药物治疗方面的知识和实践。这是一项在也门萨那进行的横断面研究，时间为 2022 年 1 月 1 日至 2023 年 1 月 31 日。向参与也门不同肿瘤中心和单位 NHL 药物治疗的 99 名医生和 164 名护士分发了两份自我管理和验证的问卷。采用方便抽样法招募参与者。采用二元逻辑回归分析来确定与护士和医生的知识和实践相关的因素。使用相关系数来检验知识和实践之间的关系。共有 77 名医生和 105 名护士完成了问卷。结果表明，54.3%的护士和 66.2%的医生对 NHL 药物治疗的知识掌握较差。在实践方面，83.8%的护士和 75.3%的医生在 NHL 药物治疗方面的实践较差。多变量逻辑回归分析表明，接受过化疗相关信息的护士与良好的知识水平显著相关，而在化疗管理部门工作的护士是良好实践的显著预测因素。在医生中，在萨那的国家肿瘤中心（NOC）工作的医生表现出良好的实践。相关性分析显示，护士的知识与其实践之间存在正相关关系。该研究结果证实了也门医生和护士在 NHL 药物治疗方面知识和实践的不足。应努力提高他们对治疗指南的理解，并改善患者护理。改善教育计划和培训机会可能有助于改善 NHL 管理中患者的预后。
