Hassan Naya Talal, Makhoul Ebrahim, Sallameh Jafar, Ghanem Abdulmunem, Rajab Samer, Ali Waseem, Alshehabi Zuheir
Department of Dermatology, Tishreen University Hospital, Latakia, Syria.
Cancer Research Center, Tishreen University, Latakia, Syria.
J Med Case Rep. 2021 Jul 28;15(1):375. doi: 10.1186/s13256-021-02977-1.
Non-Hodgkin lymphoma is the fourth most common malignancy in children, and it is not considered to be a hereditary disorder. However, it could affect members from the same family.
We are presenting two cases of Caucasian female siblings who were diagnosed with mediastinal lymphoblastic lymphoma in the same year. The two young females were presented to the emergency department with respiratory symptoms. After doing radiological investigations and biopsies, they were diagnosed with lymphoblastic lymphoma. The elder sister died before confirming the diagnosis, and the other is on chemotherapy now, with good treatment outcomes.
This case emphasizes the crucial role of precursor genetics in lymphoblastic lymphomas and suggests a strong relation between these genetics and age at symptom presentation. This is the first report of non-Hodgkin lymphoma in a pair of siblings in the pediatric population.
非霍奇金淋巴瘤是儿童中第四常见的恶性肿瘤，通常不被认为是一种遗传性疾病。然而，它可能会影响同一家族的成员。
我们报告了两例同年被诊断为纵隔淋巴母细胞淋巴瘤的白种女性同胞病例。这两名年轻女性因呼吸道症状就诊于急诊科。经过影像学检查和活检，她们被诊断为淋巴母细胞淋巴瘤。姐姐在确诊前去世，另一名患者目前正在接受化疗，治疗效果良好。
本病例强调了前体遗传学在淋巴母细胞淋巴瘤中的关键作用，并表明这些遗传学与症状出现时的年龄之间存在密切关系。这是儿科人群中一对同胞患非霍奇金淋巴瘤的首例报告。
