皮下白色脂肪组织的褐色化和动员有助于皮肤的有效修复。

The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair.

机构信息

Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong 510515, P.R. China.

出版信息

Cell Metab. 2024 Jun 4;36(6):1287-1301.e7. doi: 10.1016/j.cmet.2024.05.005.

DOI:10.1016/j.cmet.2024.05.005

PMID:38838641

Abstract

Adipocytes in dermis are considered to be important participants in skin repair and regeneration, but the role of subcutaneous white adipose tissue (sWAT) in skin repair is poorly understood. Here, we revealed the dynamic changes of sWAT during wound healing process. Lineage-tracing mouse studies revealed that sWAT would enter into the large wound bed and participate in the formation of granulation tissue. Moreover, sWAT undergoes beiging after skin injury. Inhibition of sWAT beiging by genetically silencing PRDM16, a key regulator to beiging, hindered wound healing process. The transcriptomics results suggested that beige adipocytes in sWAT abundantly express neuregulin 4 (NRG4), which regulated macrophage polarization and the function of myofibroblasts. In diabetic wounds, the beiging of sWAT was significantly suppressed. Thus, adipocytes from sWAT regulate multiple aspects of repair and may be therapeutic for inflammatory diseases and defective wound healing associated with aging and diabetes.

摘要

真皮中的脂肪细胞被认为是皮肤修复和再生的重要参与者，但皮下白色脂肪组织 (sWAT) 在皮肤修复中的作用知之甚少。在这里，我们揭示了 sWAT 在伤口愈合过程中的动态变化。谱系追踪小鼠研究表明，sWAT 会进入大的创面床并参与肉芽组织的形成。此外，sWAT 在皮肤损伤后会发生褐色化。通过基因沉默 PRDM16（褐色化的关键调节因子）抑制 sWAT 的褐色化会阻碍伤口愈合过程。转录组学结果表明，sWAT 中的褐色脂肪细胞大量表达神经调节蛋白 4 (NRG4)，它调节巨噬细胞极化和肌成纤维细胞的功能。在糖尿病伤口中，sWAT 的褐色化明显受到抑制。因此，来自 sWAT 的脂肪细胞调节修复的多个方面，并且可能对与衰老和糖尿病相关的炎症性疾病和有缺陷的伤口愈合具有治疗作用。