解析人类皮肤在单细胞分辨率下的功能异质性。

Unraveling the Functional Heterogeneity of Human Skin at Single-Cell Resolution.

机构信息

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Broad Institute of Harvard and MIT, 7 Cambridge Center, MA 02142, USA; Harvard Stem Cell Institute, 7 Divinity Avenue Cambridge, MA 02138, USA.

出版信息

Hematol Oncol Clin North Am. 2024 Oct;38(5):921-938. doi: 10.1016/j.hoc.2024.05.001. Epub 2024 Jun 4.

DOI:10.1016/j.hoc.2024.05.001

PMID:38839486

Abstract

The skin consists of several cell populations, including epithelial, immune, and stromal cells. Recently, there has been a significant increase in single-cell RNA-sequencing studies, contributing to the development of a consensus Human Skin Cell Atlas. The aim is to understand skin biology better and identify potential therapeutic targets. The present review utilized previously published single-cell RNA-sequencing datasets to explore human skin's cellular and functional heterogeneity. Additionally, it summarizes the functional significance of newly identified cell subpopulations in processes such as wound healing and aging.

摘要

皮肤由多个细胞群体组成，包括上皮细胞、免疫细胞和基质细胞。最近，单细胞 RNA 测序研究显著增加，推动了人类皮肤细胞图谱共识的发展。其目的是更好地了解皮肤生物学并确定潜在的治疗靶点。本综述利用之前发表的单细胞 RNA 测序数据集，探讨了人类皮肤的细胞和功能异质性。此外，它总结了新鉴定的细胞亚群在伤口愈合和衰老等过程中的功能意义。