Department of Geriatrics and Gerontology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Department of Interventional Cardiology, Thong Nhat Hospital, Ho Chi Minh City, Vietnam.
Sci Rep. 2024 Jun 5;14(1):12923. doi: 10.1038/s41598-024-63479-w.
This study in older hospitalized patients with heart failure with reduced ejection fraction (HFrEF) aimed to examine the prevalence of beta-blocker prescription and its associated factors. A total of 190 participants were recruited from July 2019 to July 2020. The inclusion criteria included: (1) aged ≥ 60 years, (2) having a diagnosis of chronic HFrEF in the medical records, (3) hospitalized for at least 48 h. The participants had a mean age of 75.5 ± 9.1, and 46.8% were female. Of these, 55.3% were prescribed beta-blockers during admission. To explore the factors associated with beta-blocker prescription, multivariable logistic regression analysis was applied and the results were presented as odds ratios (OR) and 95% confidence intervals (CI). On multivariate logistic regression models, higher NYHA classes (OR 0.49, 95%CI 0.26-0.94), chronic obstructive pulmonary disease (OR 0.17, 95% CI 0.04-0.85), chronic kidney disease (OR 0.40, 95% CI 0.19-0.83), and heart rate under 65 (OR 0.34, 95% CI 0.12-0.98) were associated with a reduced likelihood of prescription. In this study, we found a low rate of beta-blocker prescriptions, with only around half of the participants being prescribed beta-blockers. Further studies are needed to examine the reasons for the under-prescription of beta-blockers, and to evaluate the long-term benefits of beta-blockers in elderly patients with HFrEF in this population.
这项针对射血分数降低的心力衰竭（HFrEF）老年住院患者的研究旨在探讨β受体阻滞剂处方的流行情况及其相关因素。共有 190 名参与者于 2019 年 7 月至 2020 年 7 月入选。纳入标准包括：（1）年龄≥60 岁，（2）病历中有慢性 HFrEF 诊断，（3）住院至少 48 小时。参与者的平均年龄为 75.5±9.1 岁，46.8%为女性。其中，55.3%在住院期间被开具了β受体阻滞剂。为了探讨与β受体阻滞剂处方相关的因素，进行了多变量逻辑回归分析，并以比值比（OR）和 95%置信区间（CI）表示结果。在多变量逻辑回归模型中，较高的纽约心脏协会（NYHA）分级（OR 0.49，95%CI 0.26-0.94）、慢性阻塞性肺疾病（OR 0.17，95%CI 0.04-0.85）、慢性肾脏病（OR 0.40，95%CI 0.19-0.83）和心率低于 65（OR 0.34，95%CI 0.12-0.98）与降低处方可能性相关。在这项研究中，我们发现β受体阻滞剂的处方率较低，只有约一半的参与者被开具了β受体阻滞剂。需要进一步研究以探讨β受体阻滞剂处方不足的原因，并评估β受体阻滞剂在该人群中老年 HFrEF 患者的长期获益。
