Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Sanquan College of Xinxiang Medical University, Xinxiang, 453003, China.
Virol J. 2024 Jun 5;21(1):131. doi: 10.1186/s12985-024-02399-7.
Neonatal pulmonary hemorrhage is a late manifestation of various diseases. Premature delivery and low body weight are frequently observed as high-risk factors, characterized by acute onset, rapid progression, and high mortality rates. Pulmonary hemorrhage caused by cytomegalovirus infection in newborns with normal immune function is a rare occurrence. This case report focuses on a term neonate with normal birth weight who presented solely with nasal obstruction shortly after birth. However, 4 days after birth, the newborn experienced a sudden onset of blood gushing from both the mouth and nasal cavity. The patient was diagnosed with gastrointestinal bleeding, neonatal pneumonia and neonatal lung consolidation. And he was discharged after ten days of symptomatic treatment. However, upon returning home, the patient experienced a sudden onset of bleeding from the mouth and nose, leading to his untimely demise. Subsequent autopsy revealed the presence of pulmonary hemorrhage in newborn, which presented as interstitial pneumonia. The cause of pulmonary hemorrhage is cytomegalovirus infection. This case emphasizes the importance of pediatricians enhancing their skills in differentiating pulmonary hemorrhage, especially from cytomegalovirus pneumonia.
新生儿肺出血是多种疾病的晚期表现。早产和低体重是常见的高危因素,其特点是起病急、进展快、死亡率高。免疫功能正常的新生儿巨细胞病毒感染引起的肺出血较为罕见。本病例报告重点介绍了一例足月出生、出生体重正常的新生儿,仅在出生后不久出现鼻塞。然而,出生后 4 天,新生儿突然出现口鼻大量出血。患者被诊断为新生儿胃肠出血、新生儿肺炎和新生儿肺实变,并在对症治疗 10 天后出院。然而,当他回到家时,突然出现口鼻出血,最终不幸夭折。随后的尸检显示新生儿存在肺出血,表现为间质性肺炎。肺出血的原因是巨细胞病毒感染。本例强调了儿科医生提高鉴别肺出血能力的重要性,尤其是要与巨细胞病毒肺炎相鉴别。