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抗肿瘤免疫治疗中的纳米药物递送系统

Nanodrug Delivery Systems in Antitumor Immunotherapy.

作者信息

Guo Zishuo, Ye Jinhong, Cheng Xuehao, Wang Tieshan, Zhang Yi, Yang Kaili, Du Shouying, Li Pengyue

机构信息

Beijing University of Chinese Medicine, Beijing 102488, China.

YiDu Central Hospital of Weifang, Weifang, Shandong 262500, China.

出版信息

Biomater Res. 2024 Apr 25;28:0015. doi: 10.34133/bmr.0015. eCollection 2024.

DOI:10.34133/bmr.0015
PMID:38840653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11045275/
Abstract

Cancer has become one of the most important factors threatening human health, and the global cancer burden has been increasing rapidly. Immunotherapy has become another clinical research hotspot after surgery, chemotherapy, and radiotherapy because of its high efficiency and tumor metastasis prevention. However, problems such as lower immune response rate and immune-related adverse reaction in the clinical application of immunotherapy need to be urgently solved. With the development of nanodrug delivery systems, various nanocarrier materials have been used in the research of antitumor immunotherapy with encouraging therapeutic results. In this review, we mainly summarized the combination of nanodrug delivery systems and immunotherapy from the following 4 aspects: (a) nanodrug delivery systems combined with cytokine therapy to improve cytokines delivery in vivo; (b) nanodrug delivery systems provided a suitable platform for the combination of immune checkpoint blockade therapy with other tumor treatments; (c) nanodrug delivery systems helped deliver antigens and adjuvants for tumor vaccines to enhance immune effects; and (d) nanodrug delivery systems improved tumor treatment efficiency and reduced toxicity for adoptive cell therapy. Nanomaterials chosen by researchers to construct nanodrug delivery systems and their function were also introduced in detail. Finally, we discussed the current challenges and future prospects in combining nanodrug delivery systems with immunotherapy.

摘要

癌症已成为威胁人类健康的最重要因素之一，全球癌症负担一直在迅速增加。免疫疗法因其高效性和预防肿瘤转移的特性，已成为继手术、化疗和放疗之后的另一个临床研究热点。然而，免疫疗法临床应用中免疫反应率较低和免疫相关不良反应等问题亟待解决。随着纳米药物递送系统的发展，各种纳米载体材料已被用于抗肿瘤免疫治疗研究，并取得了令人鼓舞的治疗效果。在本综述中，我们主要从以下4个方面总结了纳米药物递送系统与免疫疗法的结合：（a）纳米药物递送系统与细胞因子疗法相结合，以改善体内细胞因子的递送；（b）纳米药物递送系统为免疫检查点阻断疗法与其他肿瘤治疗方法的联合提供了合适的平台；（c）纳米药物递送系统有助于递送肿瘤疫苗的抗原和佐剂，以增强免疫效果；（d）纳米药物递送系统提高了过继性细胞疗法的肿瘤治疗效率并降低了毒性。我们还详细介绍了研究人员选择用于构建纳米药物递送系统的纳米材料及其功能。最后，我们讨论了纳米药物递送系统与免疫疗法相结合目前面临的挑战和未来前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1aae/11045275/173e34d940b0/bmr.0015.fig.011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1aae/11045275/41c2cd786ef1/bmr.0015.fig.002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1aae/11045275/1e51b6ba9bac/bmr.0015.fig.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1aae/11045275/de92bfea5568/bmr.0015.fig.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1aae/11045275/733035a44734/bmr.0015.fig.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1aae/11045275/cdfe71871d0c/bmr.0015.fig.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1aae/11045275/84daa9328649/bmr.0015.fig.009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1aae/11045275/173e34d940b0/bmr.0015.fig.011.jpg

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