Brandon S, Cowley P, McDonald C, Neville P, Palmer R, Wellstood-Eason S
Br J Psychiatry. 1985 Feb;146:177-83. doi: 10.1192/bjp.146.2.177.
As part of the Leicester electroconvulsive therapy (ECT) study, the role of ECT in schizophrenia was investigated in a double-blind trial. The Present State Examination criteria for schizophrenia were fulfilled by 22 patients, of whom 19 gave consent and entered the trial. Neuroleptic medication was restricted during the trial period. Patients were randomly allocated to eight real ECT or eight simulated ECT. At the end of the four-week trial period, patients receiving real ECT showed a significantly greater improvement when measured on the Montgomery-Asberg Schizophrenia Scale (MASS), the visual analogue global psychopathology scale, and the depression scale. The differences on the MASS and visual analogue global psychopathology scale were not due to improvement in depressive symptoms. The superiority of real ECT was not demonstrated at the 12- and 28-week follow-up, when treatment was not controlled.
作为莱斯特电休克治疗（ECT）研究的一部分，在一项双盲试验中对ECT在精神分裂症中的作用进行了调查。22名患者符合精神分裂症的现况检查标准，其中19名患者同意并进入试验。在试验期间，抗精神病药物的使用受到限制。患者被随机分配到8次真实ECT组或8次模拟ECT组。在为期四周的试验期结束时，使用蒙哥马利-阿斯伯格精神分裂症量表（MASS）、视觉模拟整体精神病理学量表和抑郁量表进行测量时，接受真实ECT治疗的患者显示出明显更大的改善。MASS量表和视觉模拟整体精神病理学量表上的差异并非由抑郁症状的改善所致。在12周和28周的随访中，当治疗不受控制时，真实ECT的优势未得到证实。
