Department of Clinical Pharmacy Practice, School of Pharmacy & Pharmaceutical Sciences, University of California, Irvine.
Division of Oncology, Children's Hospital of Orange County, Orange, USA.
Curr Opin Oncol. 2024 Jul 1;36(4):211-222. doi: 10.1097/CCO.0000000000001033. Epub 2024 Feb 26.
Symptom burden of cancer diagnosis and treatment has led adolescents and young adult cancer patients (AYAC) and survivors to seek different self-management strategies including integrative oncology (IO) modalities. IO holds great promise to improve survivorship issues in adolescents and young adult (AYA) cancer survivors. This review aims to encompass the current evidence of IO modalities and to analyze the efficacy of IO for managing survivorship issues among AYA cancer patients and survivors.
Nineteen randomized controlled trials included in this review evaluated mind and body modalities including both physical and psychological (74%) and psychological only (26%) modalities. Most assessed IO modalities were physical activity (PA) (37%) and structured exercise (10%). Most effective IO modalities found were PA, massage, mindfulness-based stress reduction (MBSR) and light therapy for treating AYA symptom burden. The Cochrane risk of bias (RoB-2) concluded 21% studies had high risk, 58% possessed some concerns and 21% had low risk.
Although evidence has shown that a number of IO modalities may improve survivorship among AYA cancer survivors, more rigorous study designs are needed in order for these modalities to be routinely recommended for use in clinical practice.
癌症诊断和治疗带来的症状负担导致青少年和青年癌症患者（AYAC）及其幸存者寻求不同的自我管理策略，包括整合肿瘤学（IO）模式。IO 有很大的希望改善青少年和青年（AYA）癌症幸存者的生存问题。本综述旨在综述 IO 模式的现有证据，并分析 IO 对管理 AYA 癌症患者和幸存者生存问题的疗效。
本综述纳入的 19 项随机对照试验评估了身心模式，包括身体和心理（74%）以及仅心理（26%）模式。大多数评估的 IO 模式是体育活动（PA）（37%）和结构化锻炼（10%）。发现最有效的 IO 模式是 PA、按摩、正念减压（MBSR）和光疗，可用于治疗 AYA 的症状负担。Cochrane 风险偏倚（RoB-2）评估结论为，21%的研究具有高风险，58%的研究存在一些担忧，21%的研究具有低风险。
尽管有证据表明，一些 IO 模式可能改善 AYA 癌症幸存者的生存状况，但需要更严格的研究设计，以便这些模式能够在临床实践中常规推荐使用。
