Högström H, Jiborn H, Zederfeldt B, Haglund U
Eur Surg Res. 1985;17(2):128-32. doi: 10.1159/000128457.
In rats a standardized left colonic resection was performed and colonic continuity restored by an end-to-end anastomosis in one layer. The rats were subjected to an LD50 septic challenge by intraperitoneal injection of live Escherichia coli pre- or postoperatively. Controls received saline in a corresponding manner. Groups of animals were sacrificed on the 3rd or 7th postoperative day. The breaking strengths of the anastomosis and of the skin wound were measured. The collagen content of the anastomotic segments was analyzed. There were no differences in anastomotic or skin wound strength between septic animals and controls. Collagen content was unaffected. Wound healing was not influenced by sepsis in this model.
在大鼠中进行标准化的左半结肠切除术，并通过单层端端吻合恢复结肠连续性。在术前或术后通过腹腔注射活的大肠杆菌对大鼠进行半数致死量的脓毒症攻击。对照组以相应方式接受生理盐水。在术后第3天或第7天处死动物组。测量吻合口和皮肤伤口的断裂强度。分析吻合段的胶原蛋白含量。脓毒症动物和对照组之间的吻合口或皮肤伤口强度没有差异。胶原蛋白含量未受影响。在该模型中，脓毒症不影响伤口愈合。
