Divald A, Ujhelyi E, Jeney A, Lapis K, Institoris L
Exp Mol Pathol. 1985 Apr;42(2):163-6. doi: 10.1016/0014-4800(85)90024-3.
Certain biochemical parameters of acute liver injury induced by carbon tetrachloride were investigated in rats treated with prostacyclin (PGI2) and two of its derivatives. Serum glutamate oxalacetate transaminase elevation and both triglyceride accumulation and reduction of glycogen content in liver were significantly suppressed by PGI2, 7-oxo-PGI2, and 20-methyl-13,14-didehydro-2,4-m-interphenylene-PGI2 48 hr after the injury. Prostacyclins partially restored some of the parameters of injury even in doses of 10 micrograms/kg ip. When the compounds were given 24 hr after CCl4 intoxication, much more pronounced protection was observed than in the case of treatments 1 hr before administration of the hepatotoxin. Thus, all tested prostacyclins exerted significant protective effects on acute liver damage which is obtained mainly in the second phase of the injury.
在使用前列环素（PGI2）及其两种衍生物治疗的大鼠中，研究了四氯化碳诱导的急性肝损伤的某些生化参数。损伤后48小时，PGI2、7-氧代-PGI2和20-甲基-13,14-二脱氢-2,4-间亚苯基-PGI2显著抑制了血清谷氨酸草酰乙酸转氨酶升高以及肝脏中甘油三酯积累和糖原含量降低。即使以10微克/千克腹腔注射的剂量，前列环素也能部分恢复一些损伤参数。当在四氯化碳中毒24小时后给予这些化合物时，观察到的保护作用比在给予肝毒素前1小时治疗的情况更为明显。因此，所有测试的前列环素对急性肝损伤均具有显著的保护作用，这种损伤主要在损伤的第二阶段出现。
