Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilian University of Munich, Germany.
Institute of Organic Chemistry, University of Innsbruck, Austria.
Planta Med. 2024 Jun;90(7-08):641-650. doi: 10.1055/a-2225-8314. Epub 2024 Jun 6.
(garden nasturtium) is a plant with relevance in phytomedicine, appreciated not only for its pharmaceutical activities, but also for its beautiful leaves and flowers. Here, we investigated the phytochemical composition of senescent nasturtium leaves. Indeed, we identified yellow chlorophyll catabolites, also termed phylloxanthobilins, which we show to contribute to the bright yellow color of the leaves in the autumn season. Moreover, we isolated and characterized the phylloxanthobilins from , and report the identification of a pyro-phylloxanthobilin, so far only accessible by chemical synthesis. We show that the phylloxanthobilins contribute to bioactivities of by displaying strong anti-oxidative effects and , and anti-inflammatory effects as assessed by COX-1 and COX-2 enzyme inhibition, similar to other bioactive ingredients of , isoquercitrin, and chlorogenic acid. Hence, phylloxanthobilins could play a role in the efficacy of in the treatment of urinary tract infections, an established indication of With the results shown in this study, we aid in the completion of the phytochemical profile of by identifying additional bioactive natural products as relevant components of this medicinal plant.
（garden nasturtium）是一种在植物药中具有重要意义的植物，不仅因其药用活性而受到重视，还因其美丽的叶子和花朵而受到赞赏。在这里，我们研究了衰老nasturtium 叶子的植物化学成分。事实上，我们鉴定了黄色叶绿素分解产物，也称为叶黄质胆红素，我们证明这些产物有助于叶子在秋季呈现鲜艳的黄色。此外，我们从 中分离和表征了叶黄质胆红素，并报告了一种热叶黄质胆红素的鉴定，迄今为止，这种物质只能通过化学合成获得。我们表明，叶黄质胆红素通过显示强烈的抗氧化作用 和 ，以及 COX-1 和 COX-2 酶抑制的抗炎作用，类似于 、异槲皮苷和绿原酸等 的其他生物活性成分，对 具有生物活性。因此，叶黄质胆红素可能在 治疗尿路感染的疗效中发挥作用，这是 的既定适应症。通过本研究的结果，我们通过鉴定其他生物活性天然产物作为这种药用植物的相关成分，有助于完成 的植物化学特征。
