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Degradation of somatomedins by the thioredoxin system.

作者信息

Enberg G, Holmgren A

出版信息

FEBS Lett. 1985 Apr 8;183(1):52-4. doi: 10.1016/0014-5793(85)80952-2.

DOI:10.1016/0014-5793(85)80952-2
PMID:3884381
Abstract

The insulin disulfide reducing thioredoxin system from E. coli was used to investigate a possible mechanism of degradation for the two somatomedins, insulin-like growth factor I and II (IGF-I and -II). The amounts of IGF-I and -II remaining after degradation were measured by use of human placenta radioreceptor assay. The results show that both IGF-I and -II were as sensitive to disulfide reduction as insulin.

摘要

相似文献

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Degradation of somatomedins by the thioredoxin system.
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引用本文的文献

1
Rapid axoplasmic transport of insulin-like growth factor I in the sciatic nerve of adult rats.
Cell Tissue Res. 1987 Feb;247(2):241-7. doi: 10.1007/BF00218305.
2
Effects of a single cleavage in insulin-like growth factors I and II on binding to receptors, carrier proteins and antibodies.胰岛素样生长因子I和II单次切割对其与受体、载体蛋白及抗体结合的影响。
Biochem J. 1990 Mar 1;266(2):513-20. doi: 10.1042/bj2660513.
3
Development and hormonal control of thioredoxin and the thioredoxin-reductase system in the rat liver during the perinatal period.
Experientia. 1991 May 15;47(5):497-500. doi: 10.1007/BF01959954.