Simjee S, Konqui A, Razzaque Ahmed A
Dermatologica. 1985;170(2):86-9. doi: 10.1159/000249506.
3 patients with multiple sclerosis (MS) who developed severe widespread bullous pemphigoid (BP) are presented. MS preceded the presentation of BP by 13-23 years (mean 18 years). BP was confirmed histologically and immunopathologically. Upon successful therapy with steroids, no recurrence of BP was observed over a 3-5 year (mean 3.7 years) follow-up. Several abnormalities of the immune system have been reported in both diseases. It is interesting to speculate that amidst existing immunologic abnormalities in all 3 patients with MS, a specific event, immunologic or viral or both may have triggered the development of BP.
本文报告了3例多发性硬化症（MS）患者发生严重广泛大疱性类天疱疮（BP）的情况。MS在BP出现之前13 - 23年（平均18年）出现。BP经组织学和免疫病理学确诊。在使用类固醇成功治疗后，在3 - 5年（平均3.7年）的随访中未观察到BP复发。两种疾病均有一些免疫系统异常的报道。有趣的是，可以推测，在所有3例MS患者现有的免疫异常中，一个特定事件，免疫性或病毒性或两者皆有，可能触发了BP的发生。
