通过使用益生菌预防和治疗抗生素相关不良反应：综述
Prevention and treatment of antibiotics-associated adverse effects through the use of probiotics: A review.
作者信息
Yang Shuwei, Qiao Jiaqi, Zhang Meng, Kwok Lai-Yu, Matijašić Bojana Bogovič, Zhang Heping, Zhang Wenyi
机构信息
Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Huhhot 010018, China.
University of Ljubljana, Biotechnical Faculty, SI-1000 Ljubljana, Slovenia.
出版信息
J Adv Res. 2025 May;71:209-226. doi: 10.1016/j.jare.2024.06.006. Epub 2024 Jun 4.
BACKGROUND
The human gut hosts a diverse microbial community, essential for maintaining overall health. However, antibiotics, commonly prescribed for infections, can disrupt this delicate balance, leading to antibiotic-associated diarrhea, inflammatory bowel disease, obesity, and even neurological disorders. Recognizing this, probiotics have emerged as a promising strategy to counteract these adverse effects.
AIM OF REVIEW
This review aims to offer a comprehensive overview of the latest evidence concerning the utilization of probiotics in managing antibiotic-associated side effects.
KEY SCIENTIFIC CONCEPTS OF REVIEW
Probiotics play a crucial role in preserving gut homeostasis, regulating intestinal function and metabolism, and modulating the host immune system. These mechanisms serve to effectively alleviate antibiotic-associated adverse effects and enhance overall well-being.
背景
人类肠道中存在着多样化的微生物群落，这对于维持整体健康至关重要。然而，常用于治疗感染的抗生素会破坏这种微妙的平衡，导致抗生素相关性腹泻、炎症性肠病、肥胖症，甚至神经紊乱。认识到这一点后，益生菌已成为一种有前景的策略来对抗这些不良反应。
综述目的
本综述旨在全面概述有关益生菌用于管理抗生素相关副作用的最新证据。
综述的关键科学概念
益生菌在维持肠道稳态、调节肠道功能和代谢以及调节宿主免疫系统方面发挥着关键作用。这些机制有助于有效减轻抗生素相关的不良反应并增强整体健康状况。
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