Eye Center of Second Hospital, Jilin University, 218 Ziqiang Street, Nanguan District, Changchun, 130041, China.
Sci Rep. 2024 Jun 6;14(1):13044. doi: 10.1038/s41598-024-61913-7.
High intraocular pressure (IOP) is one of the early complications after pars plana vitrectomy (PPV), which may cause glaucoma and poor visual prognosis secondary to surgery. Proliferative vitreoretinopathy (PVR) is one of the complications of retinal detachment (RD) and is the main reason for the poor prognosis, which is related to different kinds of cytokines. It's essential for the basic mechanism to analyze the relative aqueous humor cytokine profiles with IOP after PPV for RD. In this study, we have collected the aqueous humor of 16 patients and qualified 27 cytokines using Luminex and compared biomarkers with the high IOP group and the normal group. As a result, the concentrations of VEGF, IL-6, FGF2, and G-CSF upregulated significantly (P < 0.05), while VEGFR2 downregulated significantly (P < 0.05) in the high IOP group. IL-6 was positively correlated with high IOP (r = 0.561, P = 0.041). Meanwhile, the concentrations of IL-6 (r = 0.543, P = 0.03), IL-5 (r = 0.576, P = 0.019), IL-15 (r = 0.614, P = 0.011), IL-4 (r = 0.517, P = 0.04), ICAM-1 (r = 0.611, P = 0.012), and G-CSF (r = 0.636, P = 0.008) were significantly associated with preoperative PVR classification, and the aqueous humor levels of IL-4 (r = 0.567, P = 0.022), HGF (r = 0.701, P = 0.005), and MCP-1 (r = 0.565, P = 0.035) are significant relative to laser points. Hence, cytokines might potentially be the therapeutic target of high IOP after PPV.
高眼压（IOP）是经睫状体平坦部玻璃体切除术（PPV）后的早期并发症之一，可能导致手术继发青光眼和视力预后不良。增生性玻璃体视网膜病变（PVR）是视网膜脱离（RD）的并发症之一，是预后不良的主要原因，与不同种类的细胞因子有关。分析 PPV 治疗 RD 后相对房水细胞因子谱与 IOP 的关系，对于探讨其基本机制至关重要。在这项研究中，我们收集了 16 名患者的房水，并使用 Luminex 合格了 27 种细胞因子，将生物标志物与高 IOP 组和正常组进行比较。结果显示，高 IOP 组中 VEGF、IL-6、FGF2 和 G-CSF 的浓度显著上调（P<0.05），而 VEGFR2 显著下调（P<0.05）。IL-6 与高 IOP 呈正相关（r=0.561，P=0.041）。同时，IL-6（r=0.543，P=0.03）、IL-5（r=0.576，P=0.019）、IL-15（r=0.614，P=0.011）、IL-4（r=0.517，P=0.04）、ICAM-1（r=0.611，P=0.012）和 G-CSF（r=0.636，P=0.008）的浓度与术前 PVR 分级显著相关，IL-4（r=0.567，P=0.022）、HGF（r=0.701，P=0.005）和 MCP-1（r=0.565，P=0.035）的房水水平与激光点显著相关。因此，细胞因子可能是 PPV 后高 IOP 的潜在治疗靶点。
