Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Eye Diseases and Optometry Institute, Department of Ophthalmology and Clinical Centre of Optometry, Peking University People's Hospital, College of Optometry, Peking University Health Science Center, Beijing, China.
Front Endocrinol (Lausanne). 2022 Jun 28;13:916789. doi: 10.3389/fendo.2022.916789. eCollection 2022.
Anti-vascular endothelial growth factor (anti-VEGF) treatment are now widely used in patients with circumscribed choroidal hemangioma (CCH), however the concentrations of VEGF and other cytokines in CCH patients have not been known before. The study was conducted to compare various cytokine concentrations in the aqueous humor of eyes with CCH and control.
A total of 16 eyes of 16 patients with CCH, and 15 eyes of 15 patients with cataract as the control group were examined. Aqueous humor samples were assessed for 30 angiogenic and inflammatory cytokines by Luminex bead-based multiplex array.
Significantly, compared with control group, higher concentrations of VEGF-A and IP-10 were found in the CCH patients (P = 0.002 and P < 0.001).
VEGF-A and IP-10 might be involved with the angiogenic and antiangiogenic process in CCH patients, which provides new insight into the pathophysiology of CCH and could be potential targets for treatment.
抗血管内皮生长因子（anti-VEGF）治疗现已广泛应用于局限性脉络膜血管瘤（CCH）患者，但 CCH 患者的 VEGF 和其他细胞因子浓度尚不清楚。本研究旨在比较 CCH 眼和对照组眼房水中各种细胞因子的浓度。
共检查了 16 例 16 只 CCH 患者的 16 只眼和 15 例 15 只白内障患者作为对照组。通过 Luminex 珠基多重阵列评估房水样本中 30 种血管生成和炎症细胞因子的浓度。
与对照组相比，CCH 患者的 VEGF-A 和 IP-10 浓度显著升高（P=0.002 和 P<0.001）。
VEGF-A 和 IP-10 可能参与了 CCH 患者的血管生成和抗血管生成过程，这为 CCH 的病理生理学提供了新的见解，并可能成为治疗的潜在靶点。
