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新冠后休止期脱发:血清铁蛋白生物标志物的诊断价值和膳食补充剂的预防价值。一项病例对照研究。

Post Covid telogen effluvium: the diagnostic value of serum ferritin biomarker and the preventive value of dietary supplements. a case control study.

机构信息

Department of Dermatology, Andrology, Sexual Medicine and STDs, Faculty of Medicine, Helwan University, Cairo, Egypt.

Department of Dermatology, Banha Educational Hospital, Ministry of Health, Banha, Egypt.

出版信息

Arch Dermatol Res. 2024 Jun 6;316(6):336. doi: 10.1007/s00403-024-03004-1.

DOI:10.1007/s00403-024-03004-1
PMID:38844670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11156737/
Abstract

Telogen effluvium is characterized by excessive hair shedding usually following a stressful event. Ferritin has been used in clinical practice as a biomarker of nonanemic iron deficiency in cases of telogen effluvium. During the years of the COVID19 pandemic, telogen effluvium was reported as a part of post covid manifestations. As ferritin was also a biomarker for inflammation in cases with covid infection, this study was designed to evaluate the value of ferritin in cases with postcovid telogen effluvium one hundred patients recovering from covid 19 for 4-12 weeks were included in the study, detailed drug and laboratory history was obtained and serum ferritin level was measured. the mean serum level of ferritin among telogen effluvium patients was significantly lower than controls (68.52 ± 126 and 137 ± 137.597 ug/L respectively). Patients with telogen effluvium used significantly more azithromycin and ivermectin and significantly less vitamin C, D, lactoferrin and zinc than the controls Although serum ferritin is lower among telogen effluvium patients, it was still higher than the cutoff value for diagnosing nonanemic iron deficiency, we suggest that it will not be a good biomarkers in these cases. Our secondary outcomes showed that dietary supplements used during active infection such as vitamin C, D, lactoferrin and zinc might have a preventive value on postcovid hair loss, while azithromycin and ivermectin could have a negative long term effect on telogen effluvium.

摘要

休止期脱发的特征是大量脱发,通常在应激事件后发生。铁蛋白在临床上已被用作休止期脱发中非缺铁性贫血的生物标志物。在 COVID-19 大流行期间,休止期脱发被报道为新冠后表现的一部分。由于铁蛋白也是新冠感染病例炎症的生物标志物,因此本研究旨在评估铁蛋白在新冠后休止期脱发中的价值。

100 名从 COVID-19 中康复 4-12 周的患者纳入了这项研究,详细记录了药物和实验室病史,并测量了血清铁蛋白水平。休止期脱发患者的平均血清铁蛋白水平明显低于对照组(分别为 68.52 ± 126 和 137 ± 137.597μg/L)。与对照组相比,患有休止期脱发的患者使用阿奇霉素和伊维菌素的比例明显更高,而使用维生素 C、D、乳铁蛋白和锌的比例明显更低。

尽管休止期脱发患者的血清铁蛋白水平较低,但仍高于诊断非缺铁性贫血的临界值,我们认为它在这些病例中不是一个好的生物标志物。我们的次要结果表明,在感染期间使用的膳食补充剂,如维生素 C、D、乳铁蛋白和锌,可能对新冠后脱发具有预防作用,而阿奇霉素和伊维菌素可能对休止期脱发具有长期的负面影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9be/11156737/850c4c0af766/403_2024_3004_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9be/11156737/850c4c0af766/403_2024_3004_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9be/11156737/850c4c0af766/403_2024_3004_Fig1_HTML.jpg

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Life (Basel). 2023 Jul 18;13(7):1576. doi: 10.3390/life13071576.
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