Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, 410082, China.
Virol J. 2024 Jun 6;21(1):132. doi: 10.1186/s12985-024-02402-1.
Tetraparvovirus is an emerging parvovirus infecting a variety of mammals and humans, and associated with human diseases including severe acute respiratory infection and acute encephalitis syndrome. In the present study, a Tetraparvovirus ungulate 1 (formerly known as bovine hokovirus) strain HNU-CBY-2023 was identified and characterized from diseased Chinese Simmental from Hunan province, China. The nearly complete genome of HNU-CBY-2023 is 5346 nt in size and showed genomic identities of 85-95.5% to the known Tetraparvovirus ungulate 1 strains from GenBank, indicating a rather genetic variation. Phylogenetic and genetic divergence analyses indicated that Tetraparvovirus ungulate 1 could be divided into two genotypes (I and II), and HNU-CBY-2023 was clustered into genotype II. This study, for the first time, identified Tetraparvovirus ungulate 1 from domestic cattle from mainland China, which will be helpful to understand the prevalence and genetic diversity of Tetraparvovirus ungulate 1.
细小病毒是一种新兴的细小病毒，感染多种哺乳动物和人类，并与包括严重急性呼吸道感染和急性脑炎综合征在内的人类疾病有关。在本研究中，从中国湖南省患病的中国西门塔尔牛中鉴定并表征了一种细小病毒偶蹄动物 1（以前称为牛疱疹病毒）株 HNU-CBY-2023。HNU-CBY-2023 的近完整基因组大小为 5346 个核苷酸，与 GenBank 中已知的细小病毒偶蹄动物 1 株的基因组同一性为 85-95.5%，表明存在相当大的遗传变异。系统进化和遗传距离分析表明，细小病毒偶蹄动物 1 可分为两个基因型（I 和 II），而 HNU-CBY-2023 则聚类为基因型 II。本研究首次从中国大陆的家牛中鉴定出细小病毒偶蹄动物 1，这将有助于了解细小病毒偶蹄动物 1 的流行情况和遗传多样性。
