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间充质干细胞衍生外泌体在不同组织再生中的作用。

Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues.

作者信息

Huang Defa, Shen Haibin, Xie Fangfang, Hu Die, Jin Qing, Hu Yuexin, Zhong Tianyu

机构信息

Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

Precision Medicine Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

出版信息

J Biol Eng. 2024 Jun 6;18(1):36. doi: 10.1186/s13036-024-00431-6.

DOI:10.1186/s13036-024-00431-6
PMID:38845032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11155050/
Abstract

Exosomes are nanovesicles with multiple components used in several applications. Mesenchymal stem cells (MSCs) are well known for their great potential in clinical applications. MSC-derived exosomes (MSC-Exos) have been shown to mediate tissue regeneration in various diseases, including neurological, autoimmune, and inflammatory diseases, cancer, ischemic heart disease, lung injury, and liver fibrosis. They can modulate the immune response by interacting with immune effector cells in the presence of anti-inflammatory compounds and are involved in intercellular communication through various types of cargo. This review summarizes the MSC-Exos-mediated tissue regeneration in various diseases, including neurological, cardiovascular, liver, kidney, articular cartilage, and oral tissue applications. In addition, we discuss the challenges and prospects of MSC-Exos in tissue regeneration.

摘要

外泌体是具有多种成分的纳米囊泡，应用于多种领域。间充质干细胞（MSCs）因其在临床应用中的巨大潜力而广为人知。已证明源自间充质干细胞的外泌体（MSC-Exos）可介导多种疾病的组织再生，包括神经疾病、自身免疫性疾病、炎症性疾病、癌症、缺血性心脏病、肺损伤和肝纤维化。它们可在存在抗炎化合物的情况下通过与免疫效应细胞相互作用来调节免疫反应，并通过各种类型的货物参与细胞间通讯。本综述总结了MSC-Exos介导的各种疾病中的组织再生，包括神经、心血管、肝脏、肾脏、关节软骨和口腔组织应用。此外，我们还讨论了MSC-Exos在组织再生中的挑战和前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fba/11155050/f03f7f6fa1ca/13036_2024_431_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fba/11155050/eb1dc90f6d41/13036_2024_431_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fba/11155050/c2819a5e3569/13036_2024_431_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fba/11155050/4b0602a69bdd/13036_2024_431_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fba/11155050/f03f7f6fa1ca/13036_2024_431_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fba/11155050/eb1dc90f6d41/13036_2024_431_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fba/11155050/c2819a5e3569/13036_2024_431_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fba/11155050/4b0602a69bdd/13036_2024_431_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fba/11155050/f03f7f6fa1ca/13036_2024_431_Fig2_HTML.jpg

相似文献

[1]
Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues.

J Biol Eng. 2024-6-6

[2]
Biogenesis, Composition and Potential Therapeutic Applications of Mesenchymal Stem Cells Derived Exosomes in Various Diseases.

Int J Nanomedicine. 2023

[3]
Current Status and Prospect of Delivery Vehicle Based on Mesenchymal Stem Cell-Derived Exosomes in Liver Diseases.

Int J Nanomedicine. 2023

[4]
Effects of Mesenchymal Stem Cell-Derived Exosomes on Autoimmune Diseases.

Front Immunol. 2021

[5]
Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages.

Stem Cell Res Ther. 2022-7-20

[6]
The Use of Mesenchymal Stem Cells and their Derived Extracellular Vesicles in Cardiovascular Disease Treatment.

Curr Stem Cell Res Ther. 2020

[7]
Enhancement of acellular cartilage matrix scaffold by Wharton's jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration.

Bioact Mater. 2021-2-13

[8]
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Biomaterials. 2019-3-20

[9]
A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation.

Acta Biomater. 2020-9-1

[10]
Exosomes Isolated From Platelet-Rich Plasma and Mesenchymal Stem Cells Promote Recovery of Function After Muscle Injury.

Am J Sports Med. 2020-6-16

引用本文的文献

[1]
Immunomodulatory and Regenerative Functions of MSC-Derived Exosomes in Bone Repair.

Bioengineering (Basel). 2025-8-5

[2]
Stem cell treatments for female reproductive disorders: a comprehensive review.

J Ovarian Res. 2025-7-24

[3]
Mesenchymal stem cell-derived exosomes and the Wnt/β-catenin pathway: Unifying mechanisms of multi-organ regeneration and the path to precision clinical translation.

World J Stem Cells. 2025-6-26

[4]
Therapeutic Potential of Umbilical Cord MSC-Derived Exosomes in a Severe Dry Eye Rat Model: Enhancing Corneal Protection and Modulating Inflammation.

Biomedicines. 2025-5-11

[5]
Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues.

Regen Ther. 2025-3-26

[6]
Mesenchymal stem cells and their exosomes: a novel approach to skin regeneration via signaling pathways activation.

J Mol Histol. 2025-4-10

[7]
Non-coding RNA-mediated granulosa cell dysfunction during ovarian aging: From mechanisms to potential interventions.

Noncoding RNA Res. 2025-3-3

[8]
Mesenchymal stem cell exosome therapy: current research status in the treatment of neurodegenerative diseases and the possibility of reversing normal brain aging.

Stem Cell Res Ther. 2025-2-21

[9]
Psoriasis: The Versatility of Mesenchymal Stem Cell and Exosome Therapies.

Biomolecules. 2024-10-24

本文引用的文献

[1]
Tumor immune escape: extracellular vesicles roles and therapeutics application.

Cell Commun Signal. 2024-1-2

[2]
Progress and prospect of nanotechnology for cardiac fibrosis treatment.

Interdiscip Med. 2023-10

[3]
A systematic literature review on direct and indirect costs of triple-negative breast cancer.

Cost Eff Resour Alloc. 2023-11-30

[4]
Biogenesis, Composition and Potential Therapeutic Applications of Mesenchymal Stem Cells Derived Exosomes in Various Diseases.

Int J Nanomedicine. 2023

[5]
Human umbilical cord mesenchymal stem cell exosomes alleviate acute kidney injury by inhibiting pyroptosis in rats and NRK-52E cells.

Ren Fail. 2023-12

[6]
Therapeutic application of mesenchymal stem cells derived exosomes in neurodegenerative diseases: A focus on non-coding RNAs cargo, drug delivery potential, perspective.

Life Sci. 2023-5-1

[7]
Human umbilical cord mesenchymal stem cell exosome-derived miR-874-3p targeting RIPK1/PGAM5 attenuates kidney tubular epithelial cell damage.

Cell Mol Biol Lett. 2023-2-7

[8]
Mesenchymal stem cells exosomal let-7a-5p improve autophagic flux and alleviate liver injury in acute-on-chronic liver failure by promoting nuclear expression of TFEB.

Cell Death Dis. 2022-10-12

[9]
Microfluidics for detection of exosomes and microRNAs in cancer: State of the art.

Mol Ther Nucleic Acids. 2022-4-27

[10]
Exosomes Derived from Senescent Endothelial Cells Contain Distinct Pro-angiogenic miRNAs and Proteins.

Cardiovasc Toxicol. 2022-6

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