Stem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.
Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan.
Biomolecules. 2024 Oct 24;14(11):1351. doi: 10.3390/biom14111351.
Mesenchymal stem cells (MSCs) are multilineage differentiating stromal cells with extensive immunomodulatory and anti-inflammatory properties. MSC-based therapy is widely used in the treatment of various pathologies, including bone and cartilage diseases, cardiac ischemia, diabetes, and neurological disorders. Along with MSCs, it is promising to study the therapeutic properties of exosomes derived from MSCs (MSC-Exo). A number of studies report that the therapeutic properties of MSC-Exo are superior to those of MSCs. In particular, MSC-Exo are used for tissue regeneration in various diseases, such as healing of skin wounds, cancer, coronary heart disease, lung injury, liver fibrosis, and neurological, autoimmune, and inflammatory diseases. In this regard, it is not surprising that the scientific community is interested in studying the therapeutic properties of MSCs and MSC-Exo in the treatment of psoriasis. This review summarizes the recent advancements from preclinical and clinical studies of MSCs and MSC-Exo in the treatment of psoriasis, and it also discusses their mechanisms of therapeutic action involved in the treatment of this disease.
间充质干细胞（MSCs）是多能分化的基质细胞，具有广泛的免疫调节和抗炎特性。基于 MSC 的治疗方法广泛用于治疗各种疾病，包括骨和软骨疾病、心肌缺血、糖尿病和神经紊乱。除了 MSCs 之外，研究 MSC 来源的外泌体（MSC-Exo）的治疗特性也很有前景。许多研究报告称，MSC-Exo 的治疗特性优于 MSCs。特别是，MSC-Exo 用于各种疾病的组织再生，例如皮肤伤口、癌症、冠心病、肺损伤、肝纤维化以及神经、自身免疫和炎症性疾病的愈合。在这方面，科学界对研究 MSCs 和 MSC-Exo 在治疗银屑病中的治疗特性感兴趣也就不足为奇了。本综述总结了 MSCs 和 MSC-Exo 在治疗银屑病的临床前和临床研究中的最新进展，还讨论了它们在治疗这种疾病中涉及的治疗作用机制。
