Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK; Lane Fox Clinical Respiratory Physiology Research Centre, Guy's and St. Thomas' NHS Foundation Trust, London, UK; Centre for Human and Applied Physiological Sciences, King's College London, UK; Department of Physiotherapy, The University of Melbourne, Australia.
Lane Fox Clinical Respiratory Physiology Research Centre, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
Aust Crit Care. 2024 Nov;37(6):912-923. doi: 10.1016/j.aucc.2024.05.005. Epub 2024 Jun 6.
Incorporating the perspectives of patients and care partners is crucial in the development of core outcome sets. One effective approach for achieving this involvement is by seeking input to refine the outcomes for consensus. The objectives of the study were to: i) to determine patient and care partner views on outcomes that should be measured in trials of physical rehabilitation interventions across the critical illness recovery continuum; (ii) to map these views with a pre-established list of thirty outcomes for potential inclusion in a core outcome set for these trials; and (iii) to identify any new outcomes that could be considered for inclusion.
A qualitative semistructured telephone interview study was conducted with a convenience sample of post-critical illness patients and care partners, as part of core outcome set development work. Anonymised interview transcripts were analysed using a framework approach, and exemplary narrative quotes from participants were reported used to illustrate outcome reporting.
Fourteen participants were recruited (male:female ratio = 8:6, age range [minimum-maximum]: 50-80 years, 13 former patients, one spouse). Time since intensive care unit discharge ranged from less than 1 year to 10 years at the time of interview. Participants described a range of outcomes that could be measured in trials of physical rehabilitation after critical illness that mapped closely with the pre-established list. No new outcomes were introduced by participants during the interviews. Experiences described by participants commonly reflected outcomes related to physical ability and performance, functional level, activities of daily living, and emotional and mental wellbeing. Participants spoke to how the different outcomes directly impacted their day-to-day lives and highlighted their priorities centred around resumption of tasks and activities that had value to them at personal, functional, and societal level.
Qualitative interviews confirmed the relevance of existing outcomes for potential inclusion in a core outcome set for trials of physical rehabilitation interventions across the critical illness recovery continuum. The added significance of our findings is to provide real-world meaning to these outcomes.
COMET Initiative, ID288, https://www.comet-initiative.org/studies/details/288.
纳入患者和护理伙伴的观点对于制定核心结局集至关重要。实现这种参与的一种有效方法是寻求意见来完善共识的结局。本研究的目的是：i）确定患者和护理伙伴对贯穿于危重病康复全过程的物理康复干预试验中应测量的结局的看法；(ii) 将这些观点与预先确定的 30 个结局列表进行映射，以考虑将其纳入这些试验的核心结局集；(iii) 确定任何可能被考虑纳入的新结局。
作为核心结局集制定工作的一部分，采用便利抽样法对患有危重病后的患者和护理伙伴进行了定性半结构式电话访谈研究。使用框架方法对匿名访谈记录进行了分析，并报告了参与者的示例叙述性引语，以说明结局报告。
共招募了 14 名参与者（男女比例 8:6，年龄范围[最小-最大]：50-80 岁，13 名前患者，1 名配偶）。从 ICU 出院到接受访谈的时间不到 1 年至 10 年不等。参与者描述了一系列可以在贯穿于危重病康复的物理康复试验中测量的结局，这些结局与预先确定的清单密切相关。参与者在访谈过程中没有提出新的结局。参与者描述的经历通常反映了与身体能力和表现、功能水平、日常生活活动以及情绪和心理健康相关的结局。参与者谈到了不同的结局如何直接影响他们的日常生活，并强调了他们的优先事项，这些优先事项集中在恢复对他们个人、功能和社会层面有价值的任务和活动上。
定性访谈证实了现有结局对于纳入贯穿于危重病康复全过程的物理康复干预试验的核心结局集的相关性。我们研究结果的附加意义在于为这些结局提供现实世界的意义。
COMET 倡议，ID288，https://www.comet-initiative.org/studies/details/288。
