Al-Saif Lira A, Aljawhri Said A, Eissa Osama G, Mahmoud Rania H, Said Eman S
Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, SAU.
Department of Laboratory, Erada Medical Rehabilitation Centre in Qassim, Ministry of Health, Buraydah, SAU.
Cureus. 2024 May 7;16(5):e59819. doi: 10.7759/cureus.59819. eCollection 2024 May.
Background Drug and substance abuse remains a major medical problem worldwide. Amphetamines are potent stimulants of the central nervous system. Amphetamine abuse is highly prevalent among drug-dependents. This study was conducted in Qassim, Saudi Arabia, to evaluate amphetamine's toxic effects on major and trace elements and their correlation with redox status. Methods The study involved amphetamine-only patients admitted to the Erada Rehabilitation Centre from March to October 2023. Urine samples were analysed from both normal subjects and amphetamine-dependent groups. Results Urinary sodium and chloride levels were significantly higher in the amphetamine-dependent group than in the control group, while their calcium levels decreased. Lipid peroxidase levels significantly increased in people with a substance use disorder (SUD), indicating oxidative stress. Together, their total antioxidant capacity decreased. Zinc (Zn), copper (Cu), lead (Pb), cadmium (Cd), sodium (Na), and total antioxidant capacity levels were positively correlated with lipid peroxidase. Conclusions Amphetamine-dependent people are more likely to experience a variety of health problems. This study found a direct correlation between an imbalance in major and trace elements and the redox status.
药物和物质滥用仍然是全球主要的医学问题。苯丙胺是中枢神经系统的强效兴奋剂。苯丙胺滥用在药物依赖者中非常普遍。本研究在沙特阿拉伯卡西姆进行,以评估苯丙胺对主要和微量元素的毒性作用及其与氧化还原状态的相关性。方法:该研究涉及2023年3月至10月入住埃拉达康复中心的仅使用苯丙胺的患者。对正常受试者和苯丙胺依赖组的尿液样本进行了分析。结果:苯丙胺依赖组的尿钠和氯水平显著高于对照组,而钙水平降低。物质使用障碍(SUD)患者的脂质过氧化物酶水平显著升高,表明存在氧化应激。同时,他们的总抗氧化能力下降。锌(Zn)、铜(Cu)、铅(Pb)、镉(Cd)、钠(Na)和总抗氧化能力水平与脂质过氧化物酶呈正相关。结论:苯丙胺依赖者更容易出现各种健康问题。本研究发现主要和微量元素失衡与氧化还原状态之间存在直接相关性。