Zhou Guilan, Li Ying, Wang Hairui, Wang Yuanyuan, Gao Yuan, Xu Juan, Wang Fengshuang, Peng Tao, Zhang Maojun, Shao Zhujun
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Shunyi District Center for Disease Control and Prevention, Beijing, China.
China CDC Wkly. 2024 May 17;6(20):437-441. doi: 10.46234/ccdcw2024.085.
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Pertussis has reemerged as a significant public health threat, primarily due to variations in strains, antimicrobial resistance, and vaccine evasion.
WHAT IS ADDED BY THIS REPORT?: All isolated strains were identified as type and exhibited resistance to erythromycin. Two strains showed a deficiency in Fha, thirty in Prn, and one strain exhibited multiple immunogen deficiencies.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: The emergence and spread of immunogen-deficient strains likely result from prolonged vaccine selection pressure, posing challenges to the efficacy of pertussis vaccines. Additionally, the ongoing dissemination of strains with high-level macrolide resistance presents a significant obstacle to clinical treatment strategies.
关于该主题已知的信息有哪些？：百日咳已再次成为重大的公共卫生威胁，主要是由于菌株变异、抗菌药物耐药性和疫苗逃逸。
本报告补充了哪些内容？：所有分离出的菌株均被鉴定为 型，并对红霉素耐药。两株菌株显示Fha缺乏，30株Prn缺乏，一株菌株表现出多种免疫原缺乏。
对公共卫生实践有哪些影响？：免疫原缺陷菌株的出现和传播可能是长期疫苗选择压力导致的，对百日咳疫苗的效力构成挑战。此外，高水平大环内酯类耐药菌株的持续传播对临床治疗策略构成重大障碍。
