Carpena Marina Xavier, Fraga Brenda Barbon, Martins-Silva Thais, Salatino-Oliveira Angélica, Genro Júlia Pasqualini, Polanczyk Guilherme V, Zeni Cristian, Schmitz Marcelo, Chazan Rodrigo, Hutz Mara Helena, Rohde Luis Augusto, Tovo-Rodrigues Luciana
Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil.
Postgraduate Program in Developmental Disorders, Universidade Presbiteriana Mackenzie, São Paulo, SP, Brazil.
Sleep Sci. 2024 Feb 29;17(2):e194-e198. doi: 10.1055/s-0043-1777787. eCollection 2024 Jun.
Insomnia is highly prevalent among individuals with Attention-Deficit/Hyperactivity Disorder (ADHD). However, the biological mechanisms shared between both conditions is still elusive. We aimed to investigate whether insomnia's genomic component is able to predict ADHD in childhood and adolescence. A Brazilian sample of 259 ADHD probands and their biological parents were included in the study. Their genomic DNA genotypes were used to construct the polygenic risk score for insomnia (Insomnia PRS), using the largest GWAS summary statistics as a discovery sample. The association was tested using logistic regression, under a case-pseudocontrol design. Insomnia PRS was nominally associated with ADHD (OR = 1.228, = 0.022), showing that the alleles that increase the risk for insomnia also increase the risk for ADHD. Our results suggest that genetic factors associated with insomnia may play a role in the ADHD genetic etiology, with both phenotypes likely to have a shared genetic mechanism.
失眠在注意力缺陷多动障碍（ADHD）患者中极为普遍。然而，这两种病症之间共有的生物学机制仍不明确。我们旨在研究失眠的基因组成分是否能够预测儿童期和青少年期的ADHD。 本研究纳入了来自巴西的259名ADHD先证者及其亲生父母作为样本。利用最大的全基因组关联研究（GWAS）汇总统计数据作为发现样本，将他们的基因组DNA基因型用于构建失眠的多基因风险评分（Insomnia PRS）。在病例-伪对照设计下，使用逻辑回归检验这种关联。 Insomnia PRS与ADHD存在名义上的关联（比值比[OR]=1.228，P=0.022），表明增加失眠风险的等位基因也会增加ADHD的风险。 我们的研究结果表明，与失眠相关的遗传因素可能在ADHD的遗传病因中起作用，这两种表型可能具有共同的遗传机制。
