College of Nursing and Health Management, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, China.
Front Public Health. 2024 May 23;12:1385542. doi: 10.3389/fpubh.2024.1385542. eCollection 2024.
Oxidative stress and chronic inflammation play an important role in the pathogenesis process of cognitive frailty (CF). Regular Baduanjin exercise could improve cognitive frailty in older adults, but it is unclear whether the effect of Baduanjin exercise on improving CF is mediated by modulating circulating oxidative stress and inflammatory process.
A total of 102 community-dwelling older adults with CF were recruited and randomly allocated into a 24-week Baduanjin exercise training group or no specific exercise intervention control group at an equal rate. Cognitive function and physical frailty index were assessed using the Montreal Cognitive Assessment (MoCA) and the Edmonton Frail Scale (EFS), as well as the oxidative stress and inflammatory cytokines were measured at baseline and after intervention.
After 24 weeks of intervention, the increased MoCA score (2.51 ± 0.32 points, < 0.001) and the decreased EFS scores (1.94 ± 0.20 points, = 0.012) in the Baduanjin group were significantly higher than those in the control group. Serum antioxidant SOD levels were increased by 10.03 ± 4.73 U/mL ( < 0.001), and the prooxidative MDA and 8-iso-PGF2α levels were decreased by -1.08 ± 0.80 nmol/mL ( = 0.030) and -86.61 ± 15.03 ng/L ( < 0.001) in the Baduanjin training group; while inflammatory cytokines IFN-γ, IL-2 and IL-4 levels were increased (1.08 ± 0.33 pg./mL, = 0.034, 2.74 ± 0.75 pg./mL, = 0.04 and 1.48 ± 0.35 pg./mL, = 0.042). In addition, a mediation effect that Baduanjin training improved cognitive ability mediated by an increase of circulating IFN-γ and IL-2 levels were observed in this study.
Regular Baduanjin exercise training could improve the cognitive frailty of the community-dwelling older adults with CF, and modulate oxidative stress and inflammatory processes by reducing circulating pro-oxidative MDA and 8-iso-PGF2α levels and increasing anti-oxidative SOD levels, as well as impacting inflammatory cytokines IFN-γ, IL-2, and IL-4 levels. Nevertheless, the mechanism of Baduanjin exercise mediating oxidative stress and inflammatory processes should be cautious to be explained.
http://www.chictr.org.cn/index.aspx, ChiCTR1800020341.
氧化应激和慢性炎症在认知脆弱（CF）的发病机制中起着重要作用。定期练习八段锦可以改善老年人的认知脆弱，但尚不清楚八段锦运动改善 CF 的效果是否通过调节循环氧化应激和炎症过程来介导。
共招募了 102 名社区居住的 CF 老年人，并以相等的比例随机分配到 24 周的八段锦运动训练组或无特定运动干预对照组。使用蒙特利尔认知评估（MoCA）和埃德蒙顿虚弱量表（EFS）评估认知功能和身体虚弱指数，以及在基线和干预后测量氧化应激和炎症细胞因子。
经过 24 周的干预，八段锦组的 MoCA 评分增加（2.51±0.32 分，<0.001）和 EFS 评分降低（1.94±0.20 分，=0.012）明显高于对照组。血清抗氧化 SOD 水平升高 10.03±4.73 U/mL（<0.001），促氧化 MDA 和 8-iso-PGF2α 水平分别降低-1.08±0.80 nmol/mL（=0.030）和-86.61±15.03 ng/L（<0.001）；而炎性细胞因子 IFN-γ、IL-2 和 IL-4 水平升高（1.08±0.33 pg/mL，=0.034，2.74±0.75 pg/mL，=0.04 和 1.48±0.35 pg/mL，=0.042）。此外，本研究观察到八段锦训练通过增加循环 IFN-γ 和 IL-2 水平改善认知能力存在中介效应。
定期八段锦运动训练可以改善社区居住的 CF 老年人的认知脆弱，通过降低循环促氧化 MDA 和 8-iso-PGF2α 水平和增加抗氧化 SOD 水平，以及影响炎性细胞因子 IFN-γ、IL-2 和 IL-4 水平，调节氧化应激和炎症过程。然而，八段锦运动调节氧化应激和炎症过程的机制仍需谨慎解释。
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