Kudsi Maysoun, Drie Tasneem, Haidar Ghina, Hodaifa Yara, Tarcha Raghad
Damascus University.
Rheumatology Department, Faculty of Medicine, Damascus University, Syrian Arab Republic.
Ann Med Surg (Lond). 2024 Apr 24;86(6):3721-3723. doi: 10.1097/MS9.0000000000002088. eCollection 2024 Jun.
Multiple myeloma (MM) is a malignant plasma cell proliferation producing large numbers of monoclonal immunoglobulins. Typical MM symptoms include anemia, bone pain, hypercalcemia, and renal failure. Atypical presentations like joint involvement were rarely reported in the literature and may cause significant delays in treatment and adverse outcomes.
The authors report a case of a 54-year-old female who presented with symmetrical polyarthritis and was misdiagnosed with rheumatoid arthritis. The diagnosis of MM was made after failing many treatments of rheumatoid arthritis and with further laboratory tests and procedures.
This rare manifestation of MM carries a diagnostic challenge and causes a significant delay in treating such patients. Here, the authors report this unusual initial presentation with a review of several cases in the literature describing similar presentations.
多发性骨髓瘤（MM）是一种产生大量单克隆免疫球蛋白的恶性浆细胞增殖性疾病。典型的MM症状包括贫血、骨痛、高钙血症和肾衰竭。像关节受累这样的非典型表现文献中报道较少，可能会导致治疗的显著延迟和不良后果。
作者报告了一例54岁女性，表现为对称性多关节炎，被误诊为类风湿关节炎。在类风湿关节炎多次治疗失败并经过进一步实验室检查和操作后，才确诊为MM。
MM的这种罕见表现带来了诊断挑战，并导致此类患者的治疗显著延迟。在此，作者报告了这种不寻常的初始表现，并回顾了文献中几例描述类似表现的病例。
