Kim Young-Mi, Hong Suntaek
Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology, Gachon University, Incheon 21999, Republic of Korea.
Int J Oncol. 2021 Nov;59(5). doi: 10.3892/ijo.2021.5271. Epub 2021 Sep 24.
Cold‑inducible RNA‑binding protein (CIRBP) is a cold‑shock protein comprised of an RNA‑binding motif that is induced by several stressors, such as cold shock, UV radiation, nutrient deprivation, reactive oxygen species and hypoxia. CIRBP can modulate post‑transcriptional regulation of target mRNA, which is required to control DNA repair, circadian rhythms, cell growth, telomere integrity and cardiac physiology. In addition, the crucial function of CIRBP in various human diseases, including cancers and inflammatory disease, has been reported. Although CIRBP is primarily considered to be an oncogene, it may also serve a role in tumor suppression. In the present study, the controversial roles of CIRBP in various human cancers is summarized, with a focus on the interconnectivity between CIRBP and its target mRNAs involved in tumorigenesis. CIRBP may represent an important prognostic marker and therapeutic target for cancer therapy.
冷诱导RNA结合蛋白（CIRBP）是一种冷休克蛋白，由一个RNA结合基序组成，可被多种应激源诱导，如冷休克、紫外线辐射、营养剥夺、活性氧和缺氧。CIRBP可以调节靶mRNA的转录后调控，这对于控制DNA修复、昼夜节律、细胞生长、端粒完整性和心脏生理功能是必需的。此外，已有报道称CIRBP在包括癌症和炎症性疾病在内的各种人类疾病中具有关键作用。尽管CIRBP主要被认为是一种癌基因，但它也可能在肿瘤抑制中发挥作用。在本研究中，总结了CIRBP在各种人类癌症中的争议性作用，重点关注CIRBP与其参与肿瘤发生的靶mRNA之间的相互联系。CIRBP可能是癌症治疗的一个重要预后标志物和治疗靶点。
