Department of Ultrasound, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Gansu Province Clinical Research Center for Ultrasonography, Lanzhou, Gansu, China.
Clin Hemorheol Microcirc. 2024;88(1):71-79. doi: 10.3233/CH-242173.
To investigate the diagnostic value of CEUS in atypical-enhanced PTC.
The clinical data, qualitative and quantitative parameters of CEUS in 177 Iso/hyper-enhanced thyroid nodules with definite pathological results were retrospectively analyzed in the Lanzhou University Second Hospital from June 2019 to January 2021. And the clinical value of CEUS in the diagnosis of atypical-enhanced PTC was assessed using univariate and multivariate analysis.
Among the 177 thyroid nodules, 59 were benign and 118 were PTC. There were significant differences in age, enhancement border, ring enhancement, speed of wash in, speed of wash out, enhancement pattern, capsule interruption, time to peak, time to wash out, RT, TPH, and TTP (P < 0.05). Multivariate analysis showed unclear enhancement border and concentric enhancement were independent risk factors for the diagnosis of atypical-enhanced PTC by CEUS. The sensitivity, specificity, PPV, NPV, and accuracy of the model in diagnosing atypical-enhanced PTC were 88.1%, 71.2%, 86.0%, 75.0%, and 82.5%, respectively. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve was 0.910.
The diagnosis of atypical-enhanced PTC can be better performed by enhancement characteristics and time intensity curve (TIC) of CEUS, which have a good clinical application value.
探讨超声造影（CEUS）在不典型增强型甲状腺癌（PTC）中的诊断价值。
回顾性分析 2019 年 6 月至 2021 年 1 月兰州大学第二医院经病理证实的 177 个具有明确病理结果的不典型增强型甲状腺结节的临床资料、CEUS 定性和定量参数，并采用单因素和多因素分析评估 CEUS 对不典型增强型 PTC 的诊断价值。
177 个甲状腺结节中，良性 59 个，PTC 118 个。年龄、增强边界、环状增强、进增强速度、出增强速度、增强模式、包膜中断、达峰时间、洗脱时间、RT、TPH 和 TTP 等参数在两组间差异有统计学意义（P<0.05）。多因素分析显示，增强边界不清和同心增强是 CEUS 诊断不典型增强型 PTC 的独立危险因素。该模型诊断不典型增强型 PTC 的敏感度、特异度、PPV、NPV 和准确度分别为 88.1%、71.2%、86.0%、75.0%和 82.5%，ROC 曲线下面积（AUC）为 0.910。
CEUS 的增强特征和时间强度曲线（TIC）能更好地诊断不典型增强型 PTC，具有较好的临床应用价值。
