Graduate School of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan; Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan; McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan.
Cell Rep. 2024 Jun 25;43(6):114312. doi: 10.1016/j.celrep.2024.114312. Epub 2024 Jun 5.
We used a step-wheel system to examine the activity of striatal projection neurons as mice practiced stepping on complexly arranged foothold pegs in this Ferris-wheel-like device to receive reward. Sets of dorsolateral striatal projection neurons were sensitive to specific parameters of repetitive motor coordination during the runs. They responded to combinations of the parameters of continuous movements (interval, phase, and repetition), forming "chunking responses"-some for combinations of these parameters across multiple body parts. Recordings in sensorimotor cortical areas exhibited notably fewer such responses but were documented for smaller neuron sets whose heterogeneity was significant. Striatal movement encoding via chunking responsivity could provide insight into neural strategies governing effective motor control by the striatum. It is possible that the striking need for external rhythmic cuing to allow movement sequences by Parkinson's patients could, at least in part, reflect dysfunction in such striatal coding.
我们使用步进轮系统来检测纹状体投射神经元的活动，当老鼠在这个像摩天轮一样的装置上练习踩在复杂排列的立足点钉上以获得奖励时，这些神经元就会活动。在跑步过程中，一组背外侧纹状体投射神经元对重复运动协调的特定参数敏感。它们对连续运动参数（间隔、相位和重复）的组合做出反应，形成“分块反应”——有些反应跨越多个身体部位的这些参数组合。感觉运动皮层区域的记录显示，这种反应明显较少，但记录在较小的神经元组中，这些神经元组的异质性很显著。通过分块反应对纹状体运动进行编码，可以深入了解纹状体控制有效运动控制的神经策略。帕金森病患者明显需要外部节奏提示来进行运动序列，这至少部分反映了这种纹状体编码的功能障碍。
