Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, via Cintia, 80126 Naples, Italy; Institute of Biostructures and Bioimaging, CNR, via Pietro Castellino 111, 80131 Naples, Italy. Electronic address: https://twitter.com/TroRom.
Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, via Cintia, 80126 Naples, Italy.
Curr Opin Struct Biol. 2024 Aug;87:102846. doi: 10.1016/j.sbi.2024.102846. Epub 2024 Jun 7.
Since the discovery of G-quadruplex (G4) participation in vital cellular processes, the regulation of the interaction of naturally occurring G4s with the relative target proteins has emerged as a promising approach for therapeutic development. Additionally, a synthetic strategy has produced several oligonucleotide aptamers, embodying a G4 module, which exhibit relevant biological activity by binding selectively to a target protein. In this context, the G4-protein structures available in the Protein Data Bank represent a valuable molecular view of the different G4 topologies involved in protein interaction. Interestingly, recent results have shown the co-existence of G4s with other structural domains such as duplexes. Overall, these findings allow a better understanding of the mechanisms that regulate intricate biological functions and suggest new design for innovative medical treatments.
自发现 G-四链体（G4）参与重要的细胞过程以来，调节天然 G4 与相对靶蛋白的相互作用已成为治疗开发的一种有前途的方法。此外，一种合成策略已经产生了几个包含 G4 模块的寡核苷酸适体，通过选择性结合靶蛋白表现出相关的生物活性。在这种情况下，蛋白质数据库中可用的 G4-蛋白质结构代表了涉及蛋白质相互作用的不同 G4 拓扑结构的有价值的分子视图。有趣的是，最近的结果表明 G4 与其他结构域（如双链体）共存。总的来说，这些发现使我们能够更好地理解调节复杂生物学功能的机制，并为创新的医疗方法设计提供了新的思路。
