Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.
Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany; RESIST, Cluster of Excellence, Hannover Medical School, 30625 Hannover, Germany; Biomedical Research in End Stage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany; Center of Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, 30625 Hannover, Germany.
Cell Stem Cell. 2024 Jun 6;31(6):791-793. doi: 10.1016/j.stem.2024.05.006.
Chimeric antigen receptor (CAR) macrophages have broadened the landscape of anti-cancer immunotherapies to combat solid malignancies. Shah et al. introduce CARs to facilitate a CAR macrophage therapy, which aims to recruit and activate T/natural killer cells, further strengthening the overall immune response to decrease pancreatic cancer burden and metastatic spreading.
嵌合抗原受体 (CAR) 巨噬细胞拓宽了抗癌免疫疗法的领域，以对抗实体恶性肿瘤。Shah 等人引入了 CAR 来促进 CAR 巨噬细胞疗法，旨在招募和激活 T/自然杀伤细胞，进一步增强整体免疫反应，以减轻胰腺癌负担和转移扩散。
