Department of Anorectal Surgery, The Third People's Hospital of Chengdu, Chengdu, China.
Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Arch Pharm (Weinheim). 2024 Sep;357(9):e2400053. doi: 10.1002/ardp.202400053. Epub 2024 Jun 7.
Scutellarein is a flavonoid from Scutellaria baicalensis Georgi that has been shown to have a variety of pharmacological activities. This review aims to summarize the pharmacological and pharmacokinetic studies on scutellarein and provide useful information for relevant scholars. Pharmacological studies indicate that scutellarein possesses a diverse range of pharmacological properties, including but not limited to anti-inflammatory, antioxidant, antiviral, neuroprotective, hypoglycemic, hypolipidemic, anticancer, and cardiovascular protective effects. Further investigation reveals that the pharmacological effects of scutellarein are driven by multiple mechanisms. These mechanisms encompass the scavenging of free radicals, inhibition of the activation of inflammatory signaling pathways and expression of inflammatory mediators, inhibition of the activity of crucial viral proteins, suppression of gluconeogenesis, amelioration of insulin resistance, improvement of cerebral ischemia-reperfusion injury, induction of apoptosis in cancer cells, and prevention of myocardial hypertrophy, among others. In summary, these pharmacological studies suggest that scutellarein holds promise for the treatment of various diseases. It is imperative to conduct clinical studies to further elucidate the therapeutic effects of scutellarein. However, it is worth noting that studies on the pharmacokinetics reveal an inhibitory effect of scutellarein on uridine 5'-diphosphate glucuronide transferases and cytochrome P450 enzymes, potentially posing safety risks.
野黄芩苷是黄芩中的一种黄酮类化合物，具有多种药理活性。本综述旨在总结野黄芩苷的药理和药代动力学研究，为相关学者提供有用的信息。药理研究表明，野黄芩苷具有多种药理作用，包括但不限于抗炎、抗氧化、抗病毒、神经保护、降血糖、降血脂、抗癌和心血管保护作用。进一步的研究表明，野黄芩苷的药理作用是由多种机制驱动的。这些机制包括清除自由基、抑制炎症信号通路的激活和炎症介质的表达、抑制关键病毒蛋白的活性、抑制糖异生、改善胰岛素抵抗、改善脑缺血再灌注损伤、诱导癌细胞凋亡以及预防心肌肥厚等。总之，这些药理研究表明野黄芩苷有望用于治疗多种疾病。有必要进行临床研究以进一步阐明野黄芩苷的治疗效果。然而，值得注意的是，药代动力学研究表明野黄芩苷对尿苷 5'-二磷酸葡萄糖醛酸转移酶和细胞色素 P450 酶具有抑制作用，可能存在安全风险。
