Department of Agricultural, Food & Nutritional Science, University of Alberta, 116 St and 85 Ave, Edmonton, AB, T6G 2R3, Canada.
Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Support Care Cancer. 2024 Jun 7;32(7):418. doi: 10.1007/s00520-024-08620-1.
Patients with cancer often experience nutritional challenges and are vulnerable to muscle mass loss. While substantial research is directed towards understanding how nutritional interventions affect clinical outcomes, insights into patients' personal experiences during these trials remain limited. This qualitative study aimed to gain a deeper understanding of how participation in the Protein Recommendations to Increase Muscle (PRIMe) trial affected patients' relationships with food.
A subset of patients who completed a minimum of one follow-up visit in the PRIMe trial participated in a semi-structured interview about their experience implementing dietary modifications to increase protein intake. Data from 26 patients with a recent diagnosis of stage II-IV colorectal cancer (non-cachectic) were included. Interviews were audio recorded, transcribed verbatim, and qualitative content analysis was applied.
Most patients were male (65.4%) with stage II or III (69.2%) colorectal cancer and were a mean age of 57 ± 10 years. Five key themes emerged to provide a deeper understanding of patients' relationship with food after the PRIMe trial: (1) new positive perspectives on nutrition and coping with a cancer diagnosis; (2) embracing a comprehensive approach to food and nutrition; (3) facilitators promoting adherence to the intervention; (4) barriers challenging adherence to the intervention; and (5) shaping future dietary intake.
This qualitative study explored the emotional and psychological effects of a clinical nutrition trial on patients, focusing on their relationship with food. It underscored the trial's comprehensive intervention and its enduring influence on patients, extending beyond the immediate intervention phase. The role of current perspectives, motivation, and knowledge acquisition on ability to adhere to dietary changes to increase protein intake were emphasized by patients and are key considerations for both clinicians and researchers.
ClinicalTrials.gov Identifier: NCT02788955; registration posted on 2016-06-02.
癌症患者常面临营养挑战，容易出现肌肉量减少。虽然大量研究致力于了解营养干预如何影响临床结局，但对于患者在这些试验中的个人体验的了解仍然有限。本定性研究旨在深入了解参与蛋白质推荐量增加肌肉（PRIMe）试验如何影响患者与食物的关系。
完成 PRIMe 试验至少一次随访的患者亚组参与了一项半结构化访谈，内容涉及他们实施饮食调整以增加蛋白质摄入的经验。共纳入 26 例近期诊断为 II-IV 期结直肠癌（无恶液质）的患者。访谈进行了录音，并逐字转录，采用定性内容分析。
大多数患者为男性（65.4%），患有 II 期或 III 期（69.2%）结直肠癌，平均年龄为 57±10 岁。研究得出 5 个关键主题，以更深入地了解患者在 PRIMe 试验后的食物关系：（1）对营养和应对癌症诊断的新积极看法；（2）接受全面的食物和营养方法；（3）促进坚持干预的促进因素；（4）坚持干预的挑战障碍；（5）塑造未来的饮食摄入。
本定性研究探讨了临床营养试验对患者的情绪和心理影响，重点关注他们与食物的关系。它强调了试验的全面干预及其对患者的持久影响，超出了干预的直接阶段。患者强调了当前观点、动机和知识获取对增加蛋白质摄入的饮食改变坚持的能力的影响，这是临床医生和研究人员的关键考虑因素。
ClinicalTrials.gov 标识符：NCT02788955；注册于 2016 年 6 月 2 日发布。
