Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
BMC Vet Res. 2024 Jun 7;20(1):248. doi: 10.1186/s12917-024-04110-y.
Periodontal diseases are the most frequently diagnosed problem in cats. It has been well-established that periodontal diseases could not only cause various oral health issues but could also contribute to systemic diseases. Oxidative stress is a possible link between systemic diseases and periodontitis. Our study aimed to illustrate the influence of periodontitis on oxidative stress development in cats. Furthermore, the changes in the bacterial flora of the gums were investigated.
Based on the clinical and laboratory examinations, fifty cats were divided into two groups normal (n = 25) and moderate to advanced periodontitis (n = 25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), reduced (GSH) and oxidized glutathione (GSSG) were measured. In addition, samples were taken from the subgingival plaques of all cats for bacterial culture.
Serum TOS, GSSG, GSSG to GSH ratio, and oxidative stress index (OSI), calculated as the ratio of TOS to TAC in cats with periodontal disease were significantly higher, and TAC was significantly lower (p < 0.05) compared with controls. The results of bacterial culture indicated that the number of isolated bacterial colonies is higher in patients than in the control group. Additionally, the analysis of these data showed a positive association between periodontal index and oxidative stress.
Our results revealed that periodontitis in cats is related to a main oxidative stress. Furthermore, oxidant factors such as TOS and OSI, compared to antioxidant factors, may better indicate the presence of oxidative stress conditions in patients with periodontitis.
牙周病是猫最常被诊断出的问题。已经证实牙周病不仅会导致各种口腔健康问题，还可能导致全身性疾病。氧化应激是全身性疾病和牙周炎之间的可能联系。我们的研究旨在说明牙周炎对猫氧化应激发展的影响。此外，还研究了牙龈细菌菌群的变化。
基于临床和实验室检查，将 50 只猫分为两组：正常组（n=25）和中重度至重度牙周炎组（n=25）。测量血清总抗氧化能力（TAC）、总氧化状态（TOS）、还原型（GSH）和氧化型谷胱甘肽（GSSG）。此外，从所有猫的龈下斑块中取样进行细菌培养。
患有牙周病的猫的血清 TOS、GSSG、GSSG 与 GSH 的比值和氧化应激指数（OSI）显著升高，而 TAC 显著降低（p<0.05）。与对照组相比。细菌培养的结果表明，患者组分离的细菌菌落数量高于对照组。此外，对这些数据的分析表明，牙周指数与氧化应激之间存在正相关。
我们的结果表明，猫的牙周炎与主要的氧化应激有关。此外，与抗氧化因素相比，氧化因素（如 TOS 和 OSI）可能更好地表明牙周炎患者存在氧化应激状态。
