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回避性限制性食物摄入障碍:神经生物学与治疗的最新进展

Avoidant restrictive food intake disorder: recent advances in neurobiology and treatment.

作者信息

Fonseca Natasha K O, Curtarelli Vitória D, Bertoletti Juliana, Azevedo Karla, Cardinal Tiago M, Moreira Júlia D, Antunes Luciana C

机构信息

Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Ramiro Barcelos, 2400, Porto Alegre, RS, 90035-003, Brazil.

Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.

出版信息

J Eat Disord. 2024 Jun 7;12(1):74. doi: 10.1186/s40337-024-01021-z.

DOI:10.1186/s40337-024-01021-z
PMID:38849953
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11157884/
Abstract

Avoidant restrictive food intake disorder (ARFID) is an eating disorder characterized by persistent insufficient nutritional and/or energy intake. ARFID, before referred to as "selective eating disorder", was introduced recently in the DSM-5 as a replacement for and expansion of the previous diagnosis. Individuals with ARFID may limit food variety and intake due to avoidance based on the sensory characteristics of the food or related to any adverse consequences of eating without the intention of losing weight and concerns of body image. The limited understanding of avoidant and restrictive eating poses challenges to effective treatment and management, impacting directly on the growth and development of children and adolescents. The ARFID neurobiological concept has not yet been clearly defined to clinical practice for nutritionists, thereby hindering screening and impeding the development of treatment recommendations. This narrative review provide useful practical information to consult the pathophysiology, the neurobiology, the clinical features, the assessment and the treatment for healthcare professionals seeking to enhance their clinical knowledge and management of this disorder.

摘要

回避性限制性食物摄入障碍(ARFID)是一种饮食失调症,其特征是持续存在营养和/或能量摄入不足。ARFID以前被称为“选择性饮食失调”,最近在《精神疾病诊断与统计手册》第5版中被引入,作为先前诊断的替代和扩展。患有ARFID的个体可能会因基于食物的感官特征的回避或与进食的任何不良后果相关而限制食物种类和摄入量,而无意减肥和关注身体形象。对回避性和限制性饮食的有限理解给有效治疗和管理带来了挑战,直接影响儿童和青少年的生长发育。ARFID的神经生物学概念尚未明确界定给营养学家的临床实践,从而阻碍了筛查并妨碍了治疗建议的制定。这篇叙述性综述为寻求增强对该疾病临床知识和管理能力的医疗保健专业人员提供了有关病理生理学、神经生物学、临床特征、评估和治疗的有用实用信息。

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本文引用的文献

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The clinical presentation of avoidant restrictive food intake disorder in children and adolescents is largely independent of sex, autism spectrum disorder and anxiety traits.儿童和青少年回避性限制性食物摄入障碍的临床表现很大程度上与性别、自闭症谱系障碍及焦虑特质无关。
EClinicalMedicine. 2023 Aug 30;63:102190. doi: 10.1016/j.eclinm.2023.102190. eCollection 2023 Sep.
2
Assessment and Treatment of Avoidant/Restrictive Food Intake Disorder.回避/限制型食物摄入障碍的评估与治疗。
Curr Psychiatry Rep. 2023 Feb;25(2):53-64. doi: 10.1007/s11920-022-01404-6. Epub 2023 Jan 14.
3
What do we know about the epidemiology of avoidant/restrictive food intake disorder in children and adolescents? A systematic review of the literature.
神经影像学对早发性限制性饮食失调症脑机制的见解。
Nat Ment Health. 2025;3(7):780-788. doi: 10.1038/s44220-025-00447-x. Epub 2025 Jun 24.
4
Gender differences in eating disorders.饮食失调中的性别差异。
Front Nutr. 2025 Jun 2;12:1583672. doi: 10.3389/fnut.2025.1583672. eCollection 2025.
5
Exploring the role of maternal-adult-child relationship, early maladaptive schemas, and difficulties in emotion regulation in symptoms of avoidant/restrictive food intake disorder among Iranian students.探究母婴-成人-儿童关系、早期适应不良图式以及情绪调节困难在伊朗学生回避/限制性食物摄入障碍症状中的作用。
Eat Weight Disord. 2025 May 24;30(1):42. doi: 10.1007/s40519-025-01739-y.
6
Prevalence, Phenotype, and Correlates of Avoidant/Restrictive Food Intake Disorder Symptoms in the Gulf Cooperation Council: An Underserved Region.海湾合作委员会中回避/限制型食物摄入障碍症状的患病率、表型及相关因素:一个未得到充分服务的地区
Int J Eat Disord. 2025 Jun;58(6):1060-1071. doi: 10.1002/eat.24400. Epub 2025 Mar 14.
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Avoidant/restrictive food intake disorder (ARFID) symptoms in gender diverse adults and their relation to autistic traits, ADHD traits, and sensory sensitivities.性别多样化成年人的回避/限制性食物摄入障碍(ARFID)症状及其与自闭症特征、注意力缺陷多动障碍(ADHD)特征和感官敏感性的关系。
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我们对儿童和青少年回避/限制型食物摄入障碍的流行病学了解多少?文献系统评价。
Eur Eat Disord Rev. 2023 Mar;31(2):226-246. doi: 10.1002/erv.2964. Epub 2022 Dec 16.
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Cross-cultural adaptation and validation of the Nine Item ARFID Screen (NIAS) in Mexican youths.九项回避限制食物摄入障碍筛查量表(NIAS)在墨西哥青少年中的跨文化适应与验证
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Validation study on the child, adult, and parent version of the ARFID module 2.0 for the Eating Disorder Examination.饮食失调检查中ARFID模块2.0儿童版、成人版和家长版的验证研究。
Int J Eat Disord. 2022 Dec;55(12):1708-1720. doi: 10.1002/eat.23805. Epub 2022 Aug 24.
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Differential comorbidity profiles in avoidant/restrictive food intake disorder and anorexia nervosa: Does age play a role?回避/限制型食物摄入障碍和神经性厌食症的差异共病特征:年龄是否起作用?
Int J Eat Disord. 2022 Oct;55(10):1397-1403. doi: 10.1002/eat.23777. Epub 2022 Jul 18.
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Elevated Fasting Satiety-Promoting Cholecystokinin (CCK) in Avoidant/Restrictive Food Intake Disorder Compared to Healthy Controls.与健康对照组相比,避免/限制型摄食障碍患者空腹时胆囊收缩素(CCK)水平升高,促进饱腹感。
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