Philip A G
Pediatr Infect Dis. 1985 Mar-Apr;4(2):145-8. doi: 10.1097/00006454-198503000-00007.
Preliminary evidence (n = 15) with semiquantitative (latex) determinations of C-reactive protein (CRP) suggested an unreliable CRP response in systemic Group B streptococcal infection. Recent experience with sequential, quantitative determinations of CRP in 10 infants surviving GBS infection documents that CRP can rise rapidly with systemic infection and fall rapidly with appropriate treatment. One infant with asymptomatic bacteremia had no increase in CRP, but in nine others with sepsis and/or meningitis the peak concentrations were from 4.2 to 31.9 mg/dl. Duration of elevated CRP ranged from 2 days in benign illness to 17 days in severe meningitis. Two infants with neurologic sequelae had concentrations greater than 20 mg/dl. Leukopenia, neutropenia and elevated immature neutrophil:total neutrophil ratio were frequently observed at the onset of infection. Leukocyte counts may be most helpful in making an early diagnosis, whereas CRP concentrations may document response, influence duration of antibiotic therapy and provide prognostic information.
对15例系统性B族链球菌感染患者进行C反应蛋白（CRP）半定量（乳胶）测定的初步证据表明，在系统性B族链球菌感染中CRP反应不可靠。最近对10例GBS感染存活婴儿进行CRP连续定量测定的经验表明，CRP可随全身感染迅速升高，并随适当治疗迅速下降。1例无症状菌血症婴儿的CRP没有升高，但其他9例败血症和/或脑膜炎婴儿的峰值浓度为4.2至31.9mg/dl。CRP升高的持续时间从良性疾病的2天到严重脑膜炎的17天不等。2例有神经后遗症的婴儿浓度大于20mg/dl。在感染开始时经常观察到白细胞减少、中性粒细胞减少以及未成熟中性粒细胞与总中性粒细胞比值升高。白细胞计数可能对早期诊断最有帮助，而CRP浓度可能记录反应、影响抗生素治疗持续时间并提供预后信息。
