美托洛尔用于老年高血压患者：两种给药方案的比较。
Metoprolol in the aged hypertensive: a comparison of two dosage schedules.
作者信息
Martin A, Browning R C
出版信息
Postgrad Med J. 1985 Mar;61(713):225-7. doi: 10.1136/pgmj.61.713.225.
Abstract
Thirty-one patients aged 65 y or over suffering from moderate hypertension were studied for 16 weeks using a cross-over design in which metoprolol 100 mg daily and metoprolol 200 mg daily were compared. Both treatment regimes were effective in controlling hypertension and no difference was found between the two with regard to efficacy. The 100 mg regime was, however, better tolerated and we propose this as the preferred metoprolol dose for the aged hypertensive.
摘要
对31名65岁及以上的中度高血压患者进行了为期16周的研究，采用交叉设计，比较每日服用100毫克美托洛尔和每日服用200毫克美托洛尔的效果。两种治疗方案在控制高血压方面均有效，在疗效方面两者未发现差异。然而，100毫克方案的耐受性更好，我们建议将此作为老年高血压患者美托洛尔的首选剂量。
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