Department of Chemistry, Aligarh Muslim University, Aligarh-202002, India.
Babasaheb Bhimrao Ambedkar University, Lucknow-226025, India.
Bioorg Chem. 2024 Sep;150:107525. doi: 10.1016/j.bioorg.2024.107525. Epub 2024 Jun 3.
This review explores the recent advancements in the design and synthesis of pseudo-natural products (pseudo-NPs) by employing innovative principles and strategies, heralding a transformative era in chemistry and biology. Pseudo-NPs, produced through in silico fragmentation and the de novo recombination of natural product fragments, reveal compounds endowed with distinct biological activities. Their advantage lies in transcending natural product structures, fostering diverse possibilities. Research in this area over the past decade has yielded unconventional combinations of natural product fragments, leading to the identification of novel compounds possessing unique scaffolds and biological significance, thereby contributing to the discovery of new therapeutics. The pseudo-NPs exert potent biological effects through various signaling pathways. In chemical biology and medicinal chemistry, designing pseudo-NPs is an important strategy, harnessing molecular hybridization and bioinspired synthesis to generate diverse compounds with remarkable biological activities, underscoring their immense potential in drug discovery and development.
本文综述了通过创新原理和策略设计和合成拟天然产物（pseudo-NPs）的最新进展，开创了化学和生物学的新时代。通过计算机模拟断裂和天然产物片段的从头重组产生的 pseudo-NPs 揭示了具有独特生物活性的化合物。它们的优势在于超越天然产物结构，促进多样性的可能性。过去十年中，该领域的研究产生了天然产物片段的非常规组合，导致了具有独特支架和生物学意义的新型化合物的鉴定，从而为新疗法的发现做出了贡献。pseudo-NPs 通过各种信号通路发挥强大的生物学效应。在化学生物学和药物化学中，设计 pseudo-NPs 是一种重要的策略，利用分子杂交和生物启发合成来产生具有显著生物活性的多种化合物，凸显了它们在药物发现和开发中的巨大潜力。
