The rapid evolution of highly adaptable and reusable artificial intelligence models facilitates the implementation of digital twinning and has the potential to redefine cardiovascular risk prevention. Digital twinning combines vast amounts of data from diverse sources to construct virtual models of an individual. Emerging artificial intelligence models, called generalist AI, enable the processing of different types of data, including data from electronic health records, laboratory results, medical texts, imaging, genomics, or graphs. Among their unprecedented capabilities are an easy adaptation of a model to previously unseen medical tasks and the ability to reason and explain output using precise medical language derived from scientific literature, medical guidelines, or knowledge graphs. The proposed combination of a digital twinning approach with generalist AI is a path to accelerate the implementation of precision medicine and enhance early recognition and prevention of cardiovascular disease. This proposed strategy may extend to other domains to advance predictive, preventive, and precision medicine and also boost health research discoveries.