动脉粥样硬化会减少兔肺和肾中前列环素的生成。
Atherosclerosis decreased prostacyclin formation in rabbit lungs and kidneys.
作者信息
Dembińska-Kieć A, Rücker W, Schönhöfer P S
出版信息
Prostaglandins. 1979 Jun;17(6):831-8. doi: 10.1016/0090-6980(79)90056-x.
Metabolism of arachidonic acid (AA) was studied in perfused lungs and kidneys of normal and atherosclerotic rabbits by determination of PGE2, PGF2 alpha and the stable metabolites of PGI2 (6-keto-PGF1 alpha) and TXA2 (TXB2). PGI2 was the main AA metabolite formed by normal lungs and kidneys. Atherosclerosis reduced the formation of PGI2 by about 50 % in both organs. TXA2 formation was similarily decreased in lungs. In kidneys, the decrease in PGI2 formation was accompanied by an increase in PGE2 formation.
通过测定前列腺素E2（PGE2）、前列腺素F2α（PGF2α）以及前列环素（PGI2）的稳定代谢产物6-酮-前列腺素F1α（6-keto-PGF1α）和血栓素A2（TXA2）的代谢产物血栓素B2（TXB2），研究了正常和动脉粥样硬化兔的灌注肺和肾中花生四烯酸（AA）的代谢情况。PGI2是正常肺和肾形成的主要AA代谢产物。动脉粥样硬化使两个器官中PGI2的形成减少了约50%。肺中TXA2的形成也同样减少。在肾脏中，PGI2形成的减少伴随着PGE2形成的增加。
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